DegronMD - P0C024(NUDT7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V42I	TCGA-A5-A1OF	UCEC	TCGA	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1667
p.V42I	TCGA-BS-A0UF	UCEC	TCGA	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1667
p.V42I	DO230323	COCA	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1667
p.V42I	DO42568	UCEC	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1667
p.V42I	DO41488	UCEC	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1667
p.Y32H	TCGA-AP-A0LM	UCEC	TCGA	DIGGKYSHLP	CBL_PTK	27:36	Mutation altering degron motif	0.834
p.Y32H	DO43306	UCEC	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation altering degron motif	0.834
p.S41Y	TCGA-AZ-6601	COAD	TCGA	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1944
p.S41Y	DO8119	COAD	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1944
p.D18G	TCGA-EI-6882	READ	TCGA	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.0833
p.D18G	DO36531	READ	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.0833
p.R22C	TCGA-FI-A2D0	UCEC	TCGA	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1944
p.R22C	DO43891	UCEC	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1944
p.K20N	TCGA-O2-A52Q	LUSC	TCGA	DIGGKYSHLP	CBL_PTK	27:36	Mutation blocking ubiquitination signal	0.5833
p.K20N	DO219219	LUSC	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation blocking ubiquitination signal	0.5833
p.R22H	DO228696	EOPC	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1944
p.R22H	SIDM01126	Small Cell Lung Carcinoma	GDSC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1944
p.R22H	ACH-001599	Lung Cancer	CCLE	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1944
p.R22H	NCI-H64	lung	COSMIC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1944
p.K25N	DO228971	LICA	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.2778
p.A21S	DO229026	LICA	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1667
p.V42F	DO229009	LICA	ICGC	DIGGKYSHLP	CBL_PTK	27:36	Mutation rewiring degron network	0.1667
p.D27Y	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	DIGGKYSHLP	CBL_PTK	27:36	Mutation altering degron motif	0.7325
p.D27Y	ACH-000637	Esophageal Cancer	CCLE	DIGGKYSHLP	CBL_PTK	27:36	Mutation altering degron motif	0.7325
p.D27Y	KYSE-520	oesophagus	COSMIC	DIGGKYSHLP	CBL_PTK	27:36	Mutation altering degron motif	0.7325

Kaplan plot for NUDT7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUDT7

UniProt ID: P0C024

Entrez ID: 283927

Protein name: Peroxisomal coenzyme A diphosphatase NUDT7 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 7) (Nudix motif 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUDT7 in