DegronMD

Uniprot ID: P0C024

Source protein: Peroxisomal coenzyme A diphosphatase NUDT7

Source gene: NUDT7

Class: CBL_PTK

Location: 27:36

E3 ligase: CBL

DEGRON score: 0.9482

ASA_SCORE: 72.98

COIL: 0.9033

CONS_SCORE: 0.239

DSS_SCORE: 0.1395

HELIX: 0.0651

FCONS_SCORE: 0.6217

RIG_SCORE: 0.7515

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V42I	TCGA-A5-A1OF	UCEC	TCGA	DIGGKYSHLP	CBL_PTK	0.1667
p.V42I	TCGA-BS-A0UF	UCEC	TCGA	DIGGKYSHLP	CBL_PTK	0.1667
p.V42I	DO230323	COCA	ICGC	DIGGKYSHLP	CBL_PTK	0.1667
p.V42I	DO42568	UCEC	ICGC	DIGGKYSHLP	CBL_PTK	0.1667
p.V42I	DO41488	UCEC	ICGC	DIGGKYSHLP	CBL_PTK	0.1667
p.Y32H	TCGA-AP-A0LM	UCEC	TCGA	DIGGKYSHLP	CBL_PTK	0.834
p.Y32H	DO43306	UCEC	ICGC	DIGGKYSHLP	CBL_PTK	0.834
p.S41Y	TCGA-AZ-6601	COAD	TCGA	DIGGKYSHLP	CBL_PTK	0.1944
p.S41Y	DO8119	COAD	ICGC	DIGGKYSHLP	CBL_PTK	0.1944
p.D18G	TCGA-EI-6882	READ	TCGA	DIGGKYSHLP	CBL_PTK	0.0833
p.D18G	DO36531	READ	ICGC	DIGGKYSHLP	CBL_PTK	0.0833
p.R22C	TCGA-FI-A2D0	UCEC	TCGA	DIGGKYSHLP	CBL_PTK	0.1944
p.R22C	DO43891	UCEC	ICGC	DIGGKYSHLP	CBL_PTK	0.1944
p.K20N	TCGA-O2-A52Q	LUSC	TCGA	DIGGKYSHLP	CBL_PTK	0.5833
p.K20N	DO219219	LUSC	ICGC	DIGGKYSHLP	CBL_PTK	0.5833
p.R22H	DO228696	EOPC	ICGC	DIGGKYSHLP	CBL_PTK	0.1944
p.R22H	SIDM01126	Small Cell Lung Carcinoma	GDSC	DIGGKYSHLP	CBL_PTK	0.1944
p.R22H	ACH-001599	Lung Cancer	CCLE	DIGGKYSHLP	CBL_PTK	0.1944
p.R22H	NCI-H64	lung	COSMIC	DIGGKYSHLP	CBL_PTK	0.1944
p.K25N	DO228971	LICA	ICGC	DIGGKYSHLP	CBL_PTK	0.2778
p.A21S	DO229026	LICA	ICGC	DIGGKYSHLP	CBL_PTK	0.1667
p.V42F	DO229009	LICA	ICGC	DIGGKYSHLP	CBL_PTK	0.1667
p.D27Y	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	DIGGKYSHLP	CBL_PTK	0.7325
p.D27Y	ACH-000637	Esophageal Cancer	CCLE	DIGGKYSHLP	CBL_PTK	0.7325
p.D27Y	KYSE-520	oesophagus	COSMIC	DIGGKYSHLP	CBL_PTK	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C024	Peroxisomal coenzyme A diphosphatase NUDT7	CBL_PTK	27:36	DIGGKYSHLP	CBL	0.9482	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons