DegronMD - P0C0E4(RAB40AL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T244I	TCGA-B5-A11E	UCEC	TCGA	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.1667
p.T244I	DO41644	UCEC	ICGC	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.1667
p.S247F	TCGA-B6-A0IJ	BRCA	TCGA	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation blocking phosphorylation signal	0.6944
p.S247F	DO2813	BRCA	ICGC	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation blocking phosphorylation signal	0.6944
p.R251M	TCGA-D1-A103	UCEC	TCGA	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation altering degron motif	0.8632
p.R251M	DO42312	UCEC	ICGC	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation altering degron motif	0.8632
p.K258N	TCGA-VQ-A8E3	STAD	TCGA	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation altering degron motif	0.5806
p.K258N	DO51759	STAD	ICGC	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation altering degron motif	0.5806
p.S240F	DO220907	MELA	ICGC	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.0556
p.S240F	SIDM01259	B-Lymphoblastic Leukemia	GDSC	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.0556
p.S240F	ACH-002238	Leukemia	CCLE	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.0556
p.S240F	GR-ST	haematopoietic and lymphoid tissue	COSMIC	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.0556
p.I259V	SIDM00967	Ovarian Carcinoma	GDSC	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.3056
p.I259V	SIDM01173	Rhabdomyosarcoma	GDSC	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.3056
p.V260G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.2778
p.V260G	ACH-000937	Leukemia	CCLE	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.2778
p.V260G	PF-382	haematopoietic and lymphoid tissue	COSMIC	KRSSLCKVK	DEG_APCC_DBOX_1	250:258	Mutation rewiring degron network	0.2778

Kaplan plot for RAB40AL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAB40AL

UniProt ID: P0C0E4

Entrez ID: 282808

Protein name: Ras-related protein Rab-40A-like (Ras-like GTPase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAB40AL in