DegronMD

Uniprot ID: P0C0E4

Source protein: Ras-related protein Rab-40A-like

Source gene: RAB40AL

Class: DEG_APCC_DBOX_1

Location: 250:258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5024

ASA_SCORE: 102.7

COIL: 0.7879

CONS_SCORE: 0.3795

DSS_SCORE: 0.3175

HELIX: 0.1059

FCONS_SCORE: 1.117

RIG_SCORE: 0.7642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T244I	TCGA-B5-A11E	UCEC	TCGA	KRSSLCKVK	DEG_APCC_DBOX_1	0.1667
p.T244I	DO41644	UCEC	ICGC	KRSSLCKVK	DEG_APCC_DBOX_1	0.1667
p.S247F	TCGA-B6-A0IJ	BRCA	TCGA	KRSSLCKVK	DEG_APCC_DBOX_1	0.6944
p.S247F	DO2813	BRCA	ICGC	KRSSLCKVK	DEG_APCC_DBOX_1	0.6944
p.R251M	TCGA-D1-A103	UCEC	TCGA	KRSSLCKVK	DEG_APCC_DBOX_1	0.8632
p.R251M	DO42312	UCEC	ICGC	KRSSLCKVK	DEG_APCC_DBOX_1	0.8632
p.K258N	TCGA-VQ-A8E3	STAD	TCGA	KRSSLCKVK	DEG_APCC_DBOX_1	0.5806
p.K258N	DO51759	STAD	ICGC	KRSSLCKVK	DEG_APCC_DBOX_1	0.5806
p.S240F	DO220907	MELA	ICGC	KRSSLCKVK	DEG_APCC_DBOX_1	0.0556
p.S240F	SIDM01259	B-Lymphoblastic Leukemia	GDSC	KRSSLCKVK	DEG_APCC_DBOX_1	0.0556
p.S240F	ACH-002238	Leukemia	CCLE	KRSSLCKVK	DEG_APCC_DBOX_1	0.0556
p.S240F	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	KRSSLCKVK	DEG_APCC_DBOX_1	0.0556
p.I259V	SIDM00967	Ovarian Carcinoma	GDSC	KRSSLCKVK	DEG_APCC_DBOX_1	0.3056
p.I259V	SIDM01173	Rhabdomyosarcoma	GDSC	KRSSLCKVK	DEG_APCC_DBOX_1	0.3056
p.V260G	SIDM00451	T-Lymphoblastic Leukemia	GDSC	KRSSLCKVK	DEG_APCC_DBOX_1	0.2778
p.V260G	ACH-000937	Leukemia	CCLE	KRSSLCKVK	DEG_APCC_DBOX_1	0.2778
p.V260G	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	KRSSLCKVK	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C0E4	Ras-related protein Rab-40A-like	DEG_APCC_DBOX_1	250:258	KRSSLCKVK	APC,CDC20,FZR1	0.5024	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons