FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DN...
FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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GO - Biological processes (BP):
nucleosome assembly [GO:0006334]...
nucleosome assembly [GO:0006334]
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GO - Molecular function (MF):
DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]...
DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]
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GO - Cellular component (CC):
nucleosome [GO:0000786]; nucleus [GO:0005634]...
nucleosome [GO:0000786]; nucleus [GO:0005634]
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