DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LRTSLCAIW
Uniprot ID:
P0C1H6
Source protein:
Histone H2B type F-M
Source gene:
H2BW2
Class:
DEG_APCC_DBOX_1
Location:
142:150
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9381
ASA_SCORE:
77.2222
COIL:
0.386
CONS_SCORE:
0.5427
DSS_SCORE:
0.3363
HELIX:
0.5904
FCONS_SCORE:
1.9641
RIG_SCORE:
0.8767
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T138M
SIDM01045
Endometrial Carcinoma
GDSC
LRTSLCAIW
DEG_APCC_DBOX_1
0.2222
p.A148V
SIDM01086
B-Lymphoblastic Leukemia
GDSC
LRTSLCAIW
DEG_APCC_DBOX_1
0.5825
Drug responses associated with H2BW2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LRTSLCAIW
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0C1H6
Histone H2B type F-M
DEG_APCC_DBOX_1
142:150
LRTSLCAIW
APC,CDC20,FZR1
0.9381
More...