DegronMD - P0C875(FAM228B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N144H	TCGA-AZ-4315	COAD	TCGA	IPPFHD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1667
p.N144H	DO8842	COAD	ICGC	IPPFHD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1667
p.N144K	DO222602	COCA	ICGC	IPPFHD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1667
p.F145Y	DO229456	SKCA	ICGC	IPPFHD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1944
p.D165E	SIDM00330	Neuroblastoma	GDSC	IPPFHD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0556
p.D165E	LAN-6	autonomic ganglia	COSMIC	IPPFHD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.0556
p.L157S	SIDM00087	Plasma Cell Myeloma	GDSC	IPPFHD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.2778
p.L157S	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	IPPFHD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.2778
p.Q161K	SIDM00655	Other Solid Cancers	GDSC	IPPFHD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1667
p.Q161K	NCCIT	testis	COSMIC	IPPFHD	LIG_APCC_ABBA_1	150:155	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons