DegronMD

Uniprot ID: P0C875

Source protein: Protein FAM228B

Source gene: FAM228B

Class: LIG_APCC_ABBA_1

Location: 150:155

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9873

ASA_SCORE: 61.8667

COIL: 0.8458

CONS_SCORE: 0.4544

DSS_SCORE: 0.3688

HELIX: 0.0688

FCONS_SCORE: 1.2149

RIG_SCORE: 0.7702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N144H	TCGA-AZ-4315	COAD	TCGA	IPPFHD	LIG_APCC_ABBA_1	0.1667
p.N144H	DO8842	COAD	ICGC	IPPFHD	LIG_APCC_ABBA_1	0.1667
p.N144K	DO222602	COCA	ICGC	IPPFHD	LIG_APCC_ABBA_1	0.1667
p.F145Y	DO229456	SKCA	ICGC	IPPFHD	LIG_APCC_ABBA_1	0.1944
p.D165E	SIDM00330	Neuroblastoma	GDSC	IPPFHD	LIG_APCC_ABBA_1	0.0556
p.D165E	LAN-6	autonomic_ganglia	COSMIC	IPPFHD	LIG_APCC_ABBA_1	0.0556
p.L157S	SIDM00087	Plasma Cell Myeloma	GDSC	IPPFHD	LIG_APCC_ABBA_1	0.2778
p.L157S	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	IPPFHD	LIG_APCC_ABBA_1	0.2778
p.Q161K	SIDM00655	Other Solid Cancers	GDSC	IPPFHD	LIG_APCC_ABBA_1	0.1667
p.Q161K	NCCIT	testis	COSMIC	IPPFHD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C875	Protein FAM228B	LIG_APCC_ABBA_1	150:155	IPPFHD	APC,CDC20,FZR1	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons