DegronMD - P0CG21(NHLRC4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T44A	TCGA-B5-A3FC	UCEC	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.25
p.T44A	DO41871	UCEC	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.25
p.D26N	TCGA-CV-7263	HNSC	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.1389
p.D26N	DO14398	HNSC	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.1389
p.S32N	TCGA-G4-6628	COAD	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.3056
p.S32N	DO10132	COAD	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.3056
p.S39F	TCGA-GC-A6I3	BLCA	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation altering degron motif	0.6871
p.S39F	DO219025	BLCA	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation altering degron motif	0.6871
p.L40P	TCGA-UB-A7MB	LIHC	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation altering degron motif	0.7582
p.L40P	DO52318	LIHC	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation altering degron motif	0.7582
p.F24I	TCGA-ZF-AA4W	BLCA	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.0833
p.F24I	DO219089	BLCA	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.0833
p.D26E	DO225130	BRCA	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation rewiring degron network	0.1389
p.S39C	SIDM00796	Head and Neck Carcinoma	GDSC	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation altering degron motif	0.643
p.S39C	ACH-000740	Head and Neck Cancer	CCLE	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation altering degron motif	0.643
p.S39C	A253	salivary gland	COSMIC	ARQPLGSLG	DEG_APCC_DBOX_1	33:41	Mutation altering degron motif	0.643

Kaplan plot for NHLRC4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NHLRC4

UniProt ID: P0CG21

Entrez ID: 283948

Protein name: NHL-repeat-containing protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NHLRC4 in