DegronMD

Uniprot ID: P0CG21

Source protein: NHL-repeat-containing protein 4

Source gene: NHLRC4

Class: DEG_APCC_DBOX_1

Location: 33:41

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5937

ASA_SCORE: 50.9

COIL: 0.4689

CONS_SCORE: 0.6048

DSS_SCORE: 0.2844

HELIX: 0.0047

FCONS_SCORE: 0.8762

RIG_SCORE: 0.7111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T44A	TCGA-B5-A3FC	UCEC	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	0.25
p.T44A	DO41871	UCEC	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	0.25
p.D26N	TCGA-CV-7263	HNSC	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	0.1389
p.D26N	DO14398	HNSC	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	0.1389
p.S32N	TCGA-G4-6628	COAD	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	0.3056
p.S32N	DO10132	COAD	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	0.3056
p.S39F	TCGA-GC-A6I3	BLCA	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	0.6871
p.S39F	DO219025	BLCA	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	0.6871
p.L40P	TCGA-UB-A7MB	LIHC	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	0.7582
p.L40P	DO52318	LIHC	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	0.7582
p.F24I	TCGA-ZF-AA4W	BLCA	TCGA	ARQPLGSLG	DEG_APCC_DBOX_1	0.0833
p.F24I	DO219089	BLCA	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	0.0833
p.D26E	DO225130	BRCA	ICGC	ARQPLGSLG	DEG_APCC_DBOX_1	0.1389
p.S39C	SIDM00796	Head and Neck Carcinoma	GDSC	ARQPLGSLG	DEG_APCC_DBOX_1	0.643
p.S39C	ACH-000740	Head and Neck Cancer	CCLE	ARQPLGSLG	DEG_APCC_DBOX_1	0.643
p.S39C	A253	salivary_gland	COSMIC	ARQPLGSLG	DEG_APCC_DBOX_1	0.643

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0CG21	NHL-repeat-containing protein 4	DEG_APCC_DBOX_1	33:41	ARQPLGSLG	APC,CDC20,FZR1	0.5937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons