DegronMD - P0CJ85(DUX4L2)

FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.

GO - Biological processes (BP): regulation of transcription by RNA polymerase II [GO:0006357]

GO - Molecular function (MF): DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]

GO - Cellular component (CC): chromatin [GO:0000785]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
LPTPSDS	DEG_SCF_FBW7_1	FBXW7	Double homeobox protein 4-like protein 2	3:9	More..
LVWTPSQS	DEG_SCF_FBW7_1	FBXW7	Double homeobox protein 4-like protein 2	24:31	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L26P	DO51032	LAML	ICGC	LVWTPSQS	DEG_SCF_FBW7_1	24:31	Mutation altering degron motif	0.7582
p.P28L	DO229180	THCA	ICGC	LVWTPSQS	DEG_SCF_FBW7_1	24:31	Mutation altering degron motif	0.7582
p.E32A	DO229092	THCA	ICGC	LVWTPSQS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.3056
p.R40Q	DO229173	THCA	ICGC	LVWTPSQS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.0833
p.R40Q	DO229121	THCA	ICGC	LVWTPSQS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.0833

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No resistance data available for this Degron.

Kaplan plot for DUX4L2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DUX4L2

UniProt ID: P0CJ85

Entrez ID:

Protein name: Double homeobox protein 4-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for DUX4L2 in