DegronMD

Uniprot ID: P0CJ85

Source protein: Double homeobox protein 4-like protein 2

Source gene: DUX4L2

Class: DEG_SCF_FBW7_1

Location: 24:31

E3 ligase: FBXW7

DEGRON score: 0.8469

ASA_SCORE: 57.525

COIL: 0.4309

CONS_SCORE: 0.3909

DSS_SCORE: 0.4087

HELIX: 0.4904

FCONS_SCORE: 1.2775

RIG_SCORE: 0.7489

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L26P	DO51032	LAML	ICGC	LVWTPSQS	DEG_SCF_FBW7_1	0.7582
p.R40Q	DO229173	THCA	ICGC	LVWTPSQS	DEG_SCF_FBW7_1	0.0833
p.R40Q	DO229121	THCA	ICGC	LVWTPSQS	DEG_SCF_FBW7_1	0.0833
p.P28L	DO229180	THCA	ICGC	LVWTPSQS	DEG_SCF_FBW7_1	0.7582
p.E32A	DO229092	THCA	ICGC	LVWTPSQS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBX2	Double homeobox protein 4	DEG_SCF_FBW7_1	24:31	LVWTPSQS	FBXW7	0.8469	More...
P0CJ85	Double homeobox protein 4-like protein 2	DEG_SCF_FBW7_1	24:31	LVWTPSQS	FBXW7	0.8469	More...
P0CJ86	Double homeobox protein 4-like protein 3	DEG_SCF_FBW7_1	24:31	LVWTPSQS	FBXW7	0.8469	More...
P0CJ88	Double homeobox protein 4-like protein 5	DEG_SCF_FBW7_1	24:31	LVWTPSQS	FBXW7	0.8469	More...
P0CJ89	Double homeobox protein 4-like protein 6	DEG_SCF_FBW7_1	24:31	LVWTPSQS	FBXW7	0.8469	More...
P0CJ90	Double homeobox protein 4-like protein 7	DEG_SCF_FBW7_1	24:31	LVWTPSQS	FBXW7	0.8469	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons