DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LVWTPSQS
Uniprot ID:
Q9UBX2
Source protein:
Double homeobox protein 4
Source gene:
DUX4
Class:
DEG_SCF_FBW7_1
Location:
24:31
E3 ligase:
FBXW7
DEGRON score:
0.8469
ASA_SCORE:
58.35
COIL:
0.4274
CONS_SCORE:
0.3909
DSS_SCORE:
0.4087
HELIX:
0.4894
FCONS_SCORE:
1.2775
RIG_SCORE:
0.7489
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E32K
DO229148
THCA
ICGC
LVWTPSQS
DEG_SCF_FBW7_1
0.3056
p.R40W
DO229191
THCA
ICGC
LVWTPSQS
DEG_SCF_FBW7_1
0.0833
Drug responses associated with DUX4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LVWTPSQS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UBX2
Double homeobox protein 4
DEG_SCF_FBW7_1
24:31
LVWTPSQS
FBXW7
0.8469
More...
P0CJ85
Double homeobox protein 4-like protein 2
DEG_SCF_FBW7_1
24:31
LVWTPSQS
FBXW7
0.8469
More...
P0CJ86
Double homeobox protein 4-like protein 3
DEG_SCF_FBW7_1
24:31
LVWTPSQS
FBXW7
0.8469
More...
P0CJ88
Double homeobox protein 4-like protein 5
DEG_SCF_FBW7_1
24:31
LVWTPSQS
FBXW7
0.8469
More...
P0CJ89
Double homeobox protein 4-like protein 6
DEG_SCF_FBW7_1
24:31
LVWTPSQS
FBXW7
0.8469
More...
P0CJ90
Double homeobox protein 4-like protein 7
DEG_SCF_FBW7_1
24:31
LVWTPSQS
FBXW7
0.8469
More...