DegronMD - P10451(SPP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V163A	TCGA-69-7980	LUAD	TCGA	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.0556
p.V153L	TCGA-A5-A0G2	UCEC	TCGA	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.5654
p.E144D	TCGA-AG-3906	READ	TCGA	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.5647
p.D157G	TCGA-B8-5550	KIRC	TCGA	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.2222
p.P137S	TCGA-EE-A2GR	SKCM	TCGA	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.1667
p.R159Q	TCGA-FR-A728	SKCM	TCGA	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.1667
p.K146T	DO225395	BRCA	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.7306
p.K146T	DO229377	BTCA	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.7306
p.K146T	DO233807	GACA	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.7306
p.K146T	DO47793	STAD	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.7306
p.R148C	DO8778	COAD	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.8301
p.E160K	DO233747	GACA	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.1389
p.R149I	DO13863	GBM	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.8102
p.R149I	DO231031	LUSC	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.8102
p.G133C	DO228948	LICA	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.0556
p.V136A	DO23678	LUAD	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.1389
p.D156H	DO27437	LUSC	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.25
p.T158A	DO222349	STAD	ICGC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.1944
p.T138M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation blocking phosphorylation signal	0.6389
p.T138M	ACH-002048	Sarcoma	CCLE	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation blocking phosphorylation signal	0.6389
p.T138M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation blocking phosphorylation signal	0.6389
p.P137T	SIDM00783	Colorectal Carcinoma	GDSC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.1667
p.P137T	ACH-000971	Colon/Colorectal Cancer	CCLE	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.1667
p.P137T	HCT-116	large intestine	COSMIC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.1667
p.V145A	SIDM01608	Endometrial Carcinoma	GDSC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.5825
p.V145A	ACH-000990	Endometrial/Uterine Cancer	CCLE	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.5825
p.T155A	SIDM01776	Plasma Cell Myeloma	GDSC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.2778
p.T155A	ACH-001162	Myeloma	CCLE	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.2778
p.F146S	ACH-002048	Sarcoma	CCLE	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.6871
p.P163R	CHSA8926	bone	COSMIC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.0556
p.R154M	NCI-H23	lung	COSMIC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.3056
p.P150R	CHSA8926	bone	COSMIC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.7512
p.P150L	KM12	large intestine	COSMIC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.7582
p.P163L	KM12	large intestine	COSMIC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.0556
p.P155L	KM12	large intestine	COSMIC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.2778
p.R141M	NCI-H23	lung	COSMIC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.2778
p.R146M	NCI-H23	lung	COSMIC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation altering degron motif	0.8632
p.P155R	CHSA8926	bone	COSMIC	TEVFTPVVPTV	DEG_COP1_1	143:153	Mutation rewiring degron network	0.2778

Kaplan plot for SPP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPP1

UniProt ID: P10451

Entrez ID: 6696

Protein name: Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPP1 in