DegronMD

Uniprot ID: P10451

Source protein: Osteopontin

Source gene: SPP1

Class: DEG_COP1_1

Location: 143:153

E3 ligase: COP1

DEGRON score: 0.5988

ASA_SCORE: 64.1636

COIL: 0.6682

CONS_SCORE: 0.6521

DSS_SCORE: 0.4547

HELIX: 0.0197

FCONS_SCORE: 0.9509

RIG_SCORE: 0.8205

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V163A	TCGA-69-7980	LUAD	TCGA	TEVFTPVVPTV	DEG_COP1_1	0.0556
p.V153L	TCGA-A5-A0G2	UCEC	TCGA	TEVFTPVVPTV	DEG_COP1_1	0.5654
p.E144D	TCGA-AG-3906	READ	TCGA	TEVFTPVVPTV	DEG_COP1_1	0.5647
p.D157G	TCGA-B8-5550	KIRC	TCGA	TEVFTPVVPTV	DEG_COP1_1	0.2222
p.P137S	TCGA-EE-A2GR	SKCM	TCGA	TEVFTPVVPTV	DEG_COP1_1	0.1667
p.R159Q	TCGA-FR-A728	SKCM	TCGA	TEVFTPVVPTV	DEG_COP1_1	0.1667
p.K146T	DO225395	BRCA	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.7306
p.K146T	DO229377	BTCA	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.7306
p.K146T	DO233807	GACA	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.7306
p.K146T	DO47793	STAD	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.7306
p.R148C	DO8778	COAD	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.8301
p.E160K	DO233747	GACA	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.1389
p.R149I	DO13863	GBM	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.8102
p.R149I	DO231031	LUSC	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.8102
p.G133C	DO228948	LICA	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.0556
p.V136A	DO23678	LUAD	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.1389
p.D156H	DO27437	LUSC	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.25
p.T158A	DO222349	STAD	ICGC	TEVFTPVVPTV	DEG_COP1_1	0.1944
p.T138M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TEVFTPVVPTV	DEG_COP1_1	0.6389
p.T138M	ACH-002048	Sarcoma	CCLE	TEVFTPVVPTV	DEG_COP1_1	0.6389
p.T138M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	TEVFTPVVPTV	DEG_COP1_1	0.6389
p.P137T	SIDM00783	Colorectal Carcinoma	GDSC	TEVFTPVVPTV	DEG_COP1_1	0.1667
p.P137T	ACH-000971	Colon/Colorectal Cancer	CCLE	TEVFTPVVPTV	DEG_COP1_1	0.1667
p.P137T	HCT-116	large_intestine	COSMIC	TEVFTPVVPTV	DEG_COP1_1	0.1667
p.V145A	SIDM01608	Endometrial Carcinoma	GDSC	TEVFTPVVPTV	DEG_COP1_1	0.5825
p.V145A	ACH-000990	Endometrial/Uterine Cancer	CCLE	TEVFTPVVPTV	DEG_COP1_1	0.5825
p.T155A	SIDM01776	Plasma Cell Myeloma	GDSC	TEVFTPVVPTV	DEG_COP1_1	0.2778
p.T155A	ACH-001162	Myeloma	CCLE	TEVFTPVVPTV	DEG_COP1_1	0.2778
p.F146S	ACH-002048	Sarcoma	CCLE	TEVFTPVVPTV	DEG_COP1_1	0.6871
p.P163R	CHSA8926	bone	COSMIC	TEVFTPVVPTV	DEG_COP1_1	0.0556
p.R154M	NCI-H23	lung	COSMIC	TEVFTPVVPTV	DEG_COP1_1	0.3056
p.P150R	CHSA8926	bone	COSMIC	TEVFTPVVPTV	DEG_COP1_1	0.7512
p.P150L	KM12	large_intestine	COSMIC	TEVFTPVVPTV	DEG_COP1_1	0.7582
p.P163L	KM12	large_intestine	COSMIC	TEVFTPVVPTV	DEG_COP1_1	0.0556
p.P155L	KM12	large_intestine	COSMIC	TEVFTPVVPTV	DEG_COP1_1	0.2778
p.R141M	NCI-H23	lung	COSMIC	TEVFTPVVPTV	DEG_COP1_1	0.2778
p.R146M	NCI-H23	lung	COSMIC	TEVFTPVVPTV	DEG_COP1_1	0.8632
p.P155R	CHSA8926	bone	COSMIC	TEVFTPVVPTV	DEG_COP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TEVFTPVVPTV

Degron related mutations and impact score

Drug responses associated with SPP1 mutations

All proteins holding degron of TEVFTPVVPTV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10451	Osteopontin	DEG_COP1_1	143:153	TEVFTPVVPTV	COP1	0.5988	More...