DegronMD - P10721(KIT)

GO - Biological processes (BP): actin cytoskeleton reorganization [GO:0031532]; B cell differentiation [GO:0030183]; cell chemotaxis [GO:0060326]; cellular response to thyroid hormone stimulus [GO:0097067]; cytokine-mediated signaling pathway [GO:0019221]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; digestive tract development [GO:0048565]; ectopic germ cell programmed cell death [GO:0035234]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation [GO:0050673]; erythrocyte differentiation [GO:0030218]; erythropoietin-mediated signaling pathway [GO:0038162]; Fc receptor signaling pathway [GO:0038093]; germ cell migration [GO:0008354]; glycosphingolipid metabolic process [GO:0006687]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell migration [GO:0035701]; hemopoiesis [GO:0030097]; immature B cell differentiation [GO:0002327]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; lamellipodium assembly [GO:0030032]; lymphoid progenitor cell differentiation [GO:0002320]; male gonad development [GO:0008584]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; mast cell proliferation [GO:0070662]; megakaryocyte development [GO:0035855]; melanocyte adhesion [GO:0097326]; melanocyte differentiation [GO:0030318]; melanocyte migration [GO:0097324]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of programmed cell death [GO:0043069]; ovarian follicle development [GO:0001541]; pigmentation [GO:0043473]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of colon smooth muscle contraction [GO:1904343]; positive regulation of dendritic cell cytokine production [GO:0002732]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of kinase activity [GO:0033674]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of pyloric antrum smooth muscle contraction [GO:0120072]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of small intestine smooth muscle contraction [GO:1904349]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular associated smooth muscle cell differentiation [GO:1905065]; protein autophosphorylation [GO:0046777]; regulation of bile acid metabolic process [GO:1904251]; regulation of cell population proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; response to cadmium ion [GO:0046686]; signal transduction [GO:0007165]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827]; T cell differentiation [GO:0030217]; tongue development [GO:0043586]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; visual learning [GO:0008542] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G961S	TCGA-24-2267	OV	TCGA	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.0833
p.G961S	TCGA-XK-AAIW	PRAD	TCGA	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.0833
p.G961S	DO29740	OV	ICGC	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.0833
p.G961S	DO51407	PRAD	ICGC	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.0833
p.D975N	TCGA-A5-A2K3	UCEC	TCGA	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation altering degron motif	0.6932
p.D975N	DO43899	UCEC	ICGC	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation altering degron motif	0.6932
p.H973R	TCGA-CR-7402	HNSC	TCGA	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation altering degron motif	0.8244
p.H973R	DO15727	HNSC	ICGC	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation altering degron motif	0.8244
p.V972M	TCGA-D1-A103	UCEC	TCGA	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation altering degron motif	0.6097
p.V972M	DO42312	UCEC	ICGC	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation altering degron motif	0.6097
p.A964S	DO228380	LICA	ICGC	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.1667
p.D974Y	DO228948	LICA	ICGC	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation altering degron motif	0.6214
p.S967P	ACH-000970	Colon/Colorectal Cancer	CCLE	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.25
p.A964T	ACH-001369	Ovarian Cancer	CCLE	LLVHDD	LIG_APCC_ABBA_1	970:975	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIT

UniProt ID: P10721

Entrez ID: 3815

Protein name: Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIT in