DegronMD

Uniprot ID: P10721

Source protein: Mast/stem cell growth factor receptor Kit

Source gene: KIT

Class: LIG_APCC_ABBA_1

Location: 970:975

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8674

ASA_SCORE: 84.9

COIL: 0.7438

CONS_SCORE: 0.3991

DSS_SCORE: 0.806

HELIX: 0.0487

FCONS_SCORE: 0.8887

RIG_SCORE: 0.7658

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G961S	TCGA-24-2267	OV	TCGA	LLVHDD	LIG_APCC_ABBA_1	0.0833
p.G961S	TCGA-XK-AAIW	PRAD	TCGA	LLVHDD	LIG_APCC_ABBA_1	0.0833
p.G961S	DO29740	OV	ICGC	LLVHDD	LIG_APCC_ABBA_1	0.0833
p.G961S	DO51407	PRAD	ICGC	LLVHDD	LIG_APCC_ABBA_1	0.0833
p.D975N	TCGA-A5-A2K3	UCEC	TCGA	LLVHDD	LIG_APCC_ABBA_1	0.6932
p.D975N	DO43899	UCEC	ICGC	LLVHDD	LIG_APCC_ABBA_1	0.6932
p.H973R	TCGA-CR-7402	HNSC	TCGA	LLVHDD	LIG_APCC_ABBA_1	0.8244
p.H973R	DO15727	HNSC	ICGC	LLVHDD	LIG_APCC_ABBA_1	0.8244
p.V972M	TCGA-D1-A103	UCEC	TCGA	LLVHDD	LIG_APCC_ABBA_1	0.6097
p.V972M	DO42312	UCEC	ICGC	LLVHDD	LIG_APCC_ABBA_1	0.6097
p.A964S	DO228380	LICA	ICGC	LLVHDD	LIG_APCC_ABBA_1	0.1667
p.D974Y	DO228948	LICA	ICGC	LLVHDD	LIG_APCC_ABBA_1	0.6214
p.S967P	ACH-000970	Colon/Colorectal Cancer	CCLE	LLVHDD	LIG_APCC_ABBA_1	0.25
p.A964T	ACH-001369	Ovarian Cancer	CCLE	LLVHDD	LIG_APCC_ABBA_1	0.1667

Drug responses associated with KIT mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Sunitinib	15.4202
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Sorafenib	57.7181
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Imatinib	17.4625
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Dasatinib	4.9513
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Pazopanib	43.7165
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Cabozantinib	19.1626
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Linifanib	20.6562
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Masitinib	3.5505
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Amuvatinib	2.7681
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	OSI-930	28.7093
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Axitinib	4.0786
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Motesanib	40.0823
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Dasatinib	1.7886
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Sorafenib	7.1912
SIDM01259	ALL\|lymphoblastic_leukemia	p.K193fs*30 (No)	GDSC	Cediranib	2.0788
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A617fs*2 (No)	GDSC	Pazopanib	67.4576
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A617fs*2 (No)	GDSC	Cabozantinib	11.4473
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A617fs*2 (No)	GDSC	Linifanib	7.5083
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A617fs*2 (No)	GDSC	Masitinib	69.6224
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A617fs*2 (No)	GDSC	Amuvatinib	332.7469
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A617fs*2 (No)	GDSC	OSI-930	100.2948
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A617fs*2 (No)	GDSC	Axitinib	19.5956
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A617fs*2 (No)	GDSC	Motesanib	15.454
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A617fs*2 (No)	GDSC	Dasatinib	1.2869
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A617fs*2 (No)	GDSC	Sorafenib	103.46
SIDM01158	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.A617fs*2 (No)	GDSC	Cediranib	11
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	Pazopanib	11.0877
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	Cabozantinib	25.3578
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	Linifanib	9.3601
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	Masitinib	25.159
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	Amuvatinib	49.2709
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	OSI-930	56.9984
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	Axitinib	13.174
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	Motesanib	7.0388
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	Axitinib	26.978
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	Dasatinib	21.882
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	Sorafenib	22.617
SIDM00898	BRCA\|breast	p.N130D (No)	GDSC	Cediranib	6.2855
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P41fs*6 (No)	GDSC	Pazopanib	19.6129
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P41fs*6 (No)	GDSC	Cabozantinib	51.1254
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P41fs*6 (No)	GDSC	Linifanib	24.6252
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P41fs*6 (No)	GDSC	Masitinib	99.0645
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P41fs*6 (No)	GDSC	Amuvatinib	142.8871
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P41fs*6 (No)	GDSC	OSI-930	102.789
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P41fs*6 (No)	GDSC	Axitinib	47.5102
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P41fs*6 (No)	GDSC	Motesanib	21.4873
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P41fs*6 (No)	GDSC	Dasatinib	36.682
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P41fs*6 (No)	GDSC	Sorafenib	10.611
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P41fs*6 (No)	GDSC	Cediranib	18.416
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E306* (No)	GDSC	Pazopanib	19.6129
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E306* (No)	GDSC	Cabozantinib	51.1254
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E306* (No)	GDSC	Linifanib	24.6252
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E306* (No)	GDSC	Masitinib	99.0645
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E306* (No)	GDSC	Amuvatinib	142.8871
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E306* (No)	GDSC	OSI-930	102.789
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E306* (No)	GDSC	Axitinib	47.5102
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E306* (No)	GDSC	Motesanib	21.4873
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E306* (No)	GDSC	Dasatinib	36.682
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E306* (No)	GDSC	Sorafenib	10.611
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.E306* (No)	GDSC	Cediranib	18.416
SIDM00795	SKCM\|melanoma	p.S967P (Yes)	GDSC	Pazopanib	24.1089
SIDM00795	SKCM\|melanoma	p.S967P (Yes)	GDSC	Cabozantinib	9.2031
SIDM00795	SKCM\|melanoma	p.S967P (Yes)	GDSC	Linifanib	8.387
SIDM00795	SKCM\|melanoma	p.S967P (Yes)	GDSC	Masitinib	40.0437
SIDM00795	SKCM\|melanoma	p.S967P (Yes)	GDSC	Amuvatinib	161.9127
SIDM00795	SKCM\|melanoma	p.S967P (Yes)	GDSC	OSI-930	83.2221
SIDM00795	SKCM\|melanoma	p.S967P (Yes)	GDSC	Axitinib	2.5427
SIDM00795	SKCM\|melanoma	p.S967P (Yes)	GDSC	Motesanib	5.198
SIDM00795	SKCM\|melanoma	p.S967P (Yes)	GDSC	Dasatinib	31.343
SIDM00795	SKCM\|melanoma	p.S967P (Yes)	GDSC	Sorafenib	8.3466
SIDM00795	SKCM\|melanoma	p.S967P (Yes)	GDSC	Cediranib	5.6376
SIDM01228	SKCM\|melanoma	p.E640K (No)	GDSC	Pazopanib	22.4723
SIDM01228	SKCM\|melanoma	p.E640K (No)	GDSC	Cabozantinib	3.8227
SIDM01228	SKCM\|melanoma	p.E640K (No)	GDSC	Linifanib	7.9191
SIDM01228	SKCM\|melanoma	p.E640K (No)	GDSC	Masitinib	41.7256
SIDM01228	SKCM\|melanoma	p.E640K (No)	GDSC	Amuvatinib	39.1339
SIDM01228	SKCM\|melanoma	p.E640K (No)	GDSC	OSI-930	34.3481
SIDM01228	SKCM\|melanoma	p.E640K (No)	GDSC	Axitinib	6.9702
SIDM01228	SKCM\|melanoma	p.E640K (No)	GDSC	Motesanib	15.7313
SIDM01228	SKCM\|melanoma	p.E640K (No)	GDSC	Dasatinib	8.941
SIDM01228	SKCM\|melanoma	p.E640K (No)	GDSC	Sorafenib	29.132
SIDM01228	SKCM\|melanoma	p.E640K (No)	GDSC	Cediranib	10.222
SIDM01024	ESCA\|oesophagus	p.G779C (No)	GDSC	Pazopanib	11.0885
SIDM01024	ESCA\|oesophagus	p.G779C (No)	GDSC	Cabozantinib	76.1936
SIDM01024	ESCA\|oesophagus	p.G779C (No)	GDSC	Linifanib	13.5438
SIDM01024	ESCA\|oesophagus	p.G779C (No)	GDSC	Masitinib	72.5917
SIDM01024	ESCA\|oesophagus	p.G779C (No)	GDSC	Amuvatinib	71.8768
SIDM01024	ESCA\|oesophagus	p.G779C (No)	GDSC	OSI-930	100.2523
SIDM01024	ESCA\|oesophagus	p.G779C (No)	GDSC	Axitinib	36.9139
SIDM01024	ESCA\|oesophagus	p.G779C (No)	GDSC	Motesanib	3.5405
SIDM01024	ESCA\|oesophagus	p.G779C (No)	GDSC	Dasatinib	15.039
SIDM01024	ESCA\|oesophagus	p.G779C (No)	GDSC	Sorafenib	41.089
SIDM01024	ESCA\|oesophagus	p.G779C (No)	GDSC	Cediranib	18.47
SIDM01029	ESCA\|oesophagus	p.D266N (No)	GDSC	Pazopanib	12.871
SIDM01029	ESCA\|oesophagus	p.D266N (No)	GDSC	Cabozantinib	12.8769
SIDM01029	ESCA\|oesophagus	p.D266N (No)	GDSC	Linifanib	4.6616
SIDM01029	ESCA\|oesophagus	p.D266N (No)	GDSC	Masitinib	19.9314
SIDM01029	ESCA\|oesophagus	p.D266N (No)	GDSC	Amuvatinib	40.9564
SIDM01029	ESCA\|oesophagus	p.D266N (No)	GDSC	OSI-930	65.7888
SIDM01029	ESCA\|oesophagus	p.D266N (No)	GDSC	Axitinib	13.1772
SIDM01029	ESCA\|oesophagus	p.D266N (No)	GDSC	Motesanib	13.1533
SIDM01029	ESCA\|oesophagus	p.D266N (No)	GDSC	Dasatinib	0.1469
SIDM01029	ESCA\|oesophagus	p.D266N (No)	GDSC	Sorafenib	9.7367
SIDM01029	ESCA\|oesophagus	p.D266N (No)	GDSC	Cediranib	4.646
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R112I (No)	GDSC	Pazopanib	11.1343
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R112I (No)	GDSC	Cabozantinib	58.075
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R112I (No)	GDSC	Linifanib	18.1497
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R112I (No)	GDSC	Masitinib	74.6068
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R112I (No)	GDSC	Amuvatinib	57.1651
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R112I (No)	GDSC	OSI-930	80.2417
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R112I (No)	GDSC	Axitinib	5.407
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R112I (No)	GDSC	Motesanib	11.8955
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R112I (No)	GDSC	Dasatinib	27.442
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R112I (No)	GDSC	Sorafenib	5.6511
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.R112I (No)	GDSC	Cediranib	188.3
SIDM01032	ESCA\|oesophagus	p.A794E (No)	GDSC	Pazopanib	118.5109
SIDM01032	ESCA\|oesophagus	p.A794E (No)	GDSC	Cabozantinib	17.0263
SIDM01032	ESCA\|oesophagus	p.A794E (No)	GDSC	Linifanib	27.0999
SIDM01032	ESCA\|oesophagus	p.A794E (No)	GDSC	Masitinib	28.8394
SIDM01032	ESCA\|oesophagus	p.A794E (No)	GDSC	Amuvatinib	73.3011
SIDM01032	ESCA\|oesophagus	p.A794E (No)	GDSC	OSI-930	60.309
SIDM01032	ESCA\|oesophagus	p.A794E (No)	GDSC	Axitinib	20.1149
SIDM01032	ESCA\|oesophagus	p.A794E (No)	GDSC	Motesanib	16.1564
SIDM01032	ESCA\|oesophagus	p.A794E (No)	GDSC	Dasatinib	3.225
SIDM01032	ESCA\|oesophagus	p.A794E (No)	GDSC	Sorafenib	7.7169
SIDM01032	ESCA\|oesophagus	p.A794E (No)	GDSC	Cediranib	4.8151
SIDM00603	HNSC\|head_and_neck	p.T304A (No)	GDSC	Pazopanib	93.158
SIDM00603	HNSC\|head_and_neck	p.T304A (No)	GDSC	Cabozantinib	8.1668
SIDM00603	HNSC\|head_and_neck	p.T304A (No)	GDSC	Linifanib	11.3017
SIDM00603	HNSC\|head_and_neck	p.T304A (No)	GDSC	Masitinib	245.7695
SIDM00603	HNSC\|head_and_neck	p.T304A (No)	GDSC	Amuvatinib	338.5426
SIDM00603	HNSC\|head_and_neck	p.T304A (No)	GDSC	OSI-930	166.641
SIDM00603	HNSC\|head_and_neck	p.T304A (No)	GDSC	Axitinib	6.7659
SIDM00603	HNSC\|head_and_neck	p.T304A (No)	GDSC	Motesanib	12.4425
SIDM00777	COREAD\|large_intestine	p.T67S (No)	GDSC	Axitinib	14.3389
SIDM00777	COREAD\|large_intestine	p.T67S (No)	GDSC	Motesanib	136.1643
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Sunitinib	2.0565
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Sorafenib	4.9994
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Imatinib	8.9862
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Dasatinib	0.899
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Pazopanib	9.0608
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Cabozantinib	1.7755
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Linifanib	4.2428
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Masitinib	8.8751
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Amuvatinib	23.5168
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	OSI-930	10.8303
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Axitinib	2.2297
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Motesanib	12.841
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Dasatinib	0.7811
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Sorafenib	3.5437
SIDM01007	ALL\|lymphoblastic_leukemia	p.D131N (No)	GDSC	Cediranib	3.4309
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Sunitinib	3.3541
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Sorafenib	13.2467
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Imatinib	35.4344
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Dasatinib	0.441
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Pazopanib	36.6231
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Cabozantinib	10.286
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Linifanib	21.4251
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Masitinib	244.0592
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Amuvatinib	361.8269
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	OSI-930	201.2603
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Axitinib	7.4742
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Motesanib	24.9519
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Dasatinib	5.2806
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Sorafenib	11.215
SIDM00801	SKCM\|melanoma	p.S967P (Yes)	GDSC	Cediranib	7.6401
SIDM00980	STAD\|stomach	p.T232M (No)	GDSC	Pazopanib	28.5898
SIDM00980	STAD\|stomach	p.T232M (No)	GDSC	Cabozantinib	9.767
SIDM00980	STAD\|stomach	p.T232M (No)	GDSC	Linifanib	12.4528
SIDM00980	STAD\|stomach	p.T232M (No)	GDSC	Masitinib	49.6368
SIDM00980	STAD\|stomach	p.T232M (No)	GDSC	Amuvatinib	37.3713
SIDM00980	STAD\|stomach	p.T232M (No)	GDSC	OSI-930	96.1391
SIDM00980	STAD\|stomach	p.T232M (No)	GDSC	Axitinib	18.875
SIDM00980	STAD\|stomach	p.T232M (No)	GDSC	Motesanib	5.6922
SIDM00980	STAD\|stomach	p.T232M (No)	GDSC	Dasatinib	3.3233
SIDM00980	STAD\|stomach	p.T232M (No)	GDSC	Sorafenib	11.903
SIDM00980	STAD\|stomach	p.T232M (No)	GDSC	Cediranib	5.3843
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Sunitinib	7.909
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Sorafenib	12.8516
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Imatinib	10.8012
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Dasatinib	2.2828
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Pazopanib	17.083
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Cabozantinib	9.4361
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Linifanib	4.9982
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Masitinib	11.6279
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Amuvatinib	7.8774
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	OSI-930	87.9951
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Axitinib	3.2587
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Motesanib	12.0502
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Dasatinib	3.5891
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Sorafenib	4.5822
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R205W (No)	GDSC	Cediranib	2.9691
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Sunitinib	6.977
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Sorafenib	3.7366
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Imatinib	19.0757
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Dasatinib	0.398
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Pazopanib	10.8066
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Cabozantinib	6.127
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Linifanib	9.4403
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Masitinib	23.5032
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Amuvatinib	12.6266
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	OSI-930	20.4237
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Axitinib	18.6305
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Motesanib	18.9325
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Dasatinib	6.118
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Sorafenib	7.9392
SIDM01090	COREAD\|large_intestine	p.N400S (No)	GDSC	Cediranib	13.841
SIDM00498	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Cabozantinib	38.4248
SIDM00498	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Linifanib	9.7285
SIDM00498	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Masitinib	155.0418
SIDM00498	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Amuvatinib	54.979
SIDM00498	COREAD\|large_intestine	p.S967P (Yes)	GDSC	OSI-930	131.2117
SIDM00498	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Axitinib	6.6911
SIDM00498	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Motesanib	25.1497
SIDM00498	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Dasatinib	4.3462
SIDM00498	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Sorafenib	11.665
SIDM00498	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Cediranib	12.909
SIDM00551	ESCA\|oesophagus	p.E191K (No)	GDSC	Pazopanib	113.8277
SIDM00551	ESCA\|oesophagus	p.E191K (No)	GDSC	Cabozantinib	27.0342
SIDM00551	ESCA\|oesophagus	p.E191K (No)	GDSC	Linifanib	9.9664
SIDM00551	ESCA\|oesophagus	p.E191K (No)	GDSC	Masitinib	48.1681
SIDM00551	ESCA\|oesophagus	p.E191K (No)	GDSC	Amuvatinib	204.7277
SIDM00551	ESCA\|oesophagus	p.E191K (No)	GDSC	OSI-930	146.077
SIDM00551	ESCA\|oesophagus	p.E191K (No)	GDSC	Axitinib	9.7017
SIDM00551	ESCA\|oesophagus	p.E191K (No)	GDSC	Motesanib	18.2361
SIDM00551	ESCA\|oesophagus	p.E191K (No)	GDSC	Dasatinib	2.9656
SIDM00551	ESCA\|oesophagus	p.E191K (No)	GDSC	Sorafenib	9.7666
SIDM00551	ESCA\|oesophagus	p.E191K (No)	GDSC	Cediranib	5.3205
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Sunitinib	8.9213
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Sorafenib	9.5131
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Imatinib	29.9004
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Dasatinib	0.6739
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Pazopanib	31.1062
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Cabozantinib	8.6552
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Linifanib	14.017
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Masitinib	16.6885
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Amuvatinib	102.5182
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	OSI-930	40.8188
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Axitinib	34.3358
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Motesanib	24.8288
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Dasatinib	2.4148
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Sorafenib	6.2141
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N400S (No)	GDSC	Cediranib	5.0361
SIDM01045	UCEC\|endometrium	p.T304A (No)	GDSC	Pazopanib	25.9455
SIDM01045	UCEC\|endometrium	p.T304A (No)	GDSC	Cabozantinib	11.3765
SIDM01045	UCEC\|endometrium	p.T304A (No)	GDSC	Linifanib	22.6931
SIDM01045	UCEC\|endometrium	p.T304A (No)	GDSC	Masitinib	125.144
SIDM01045	UCEC\|endometrium	p.T304A (No)	GDSC	Amuvatinib	71.3879
SIDM01045	UCEC\|endometrium	p.T304A (No)	GDSC	OSI-930	175.3846
SIDM01045	UCEC\|endometrium	p.T304A (No)	GDSC	Axitinib	2.9808
SIDM01045	UCEC\|endometrium	p.T304A (No)	GDSC	Motesanib	50.6745
SIDM01045	UCEC\|endometrium	p.T304A (No)	GDSC	Dasatinib	113.48
SIDM01045	UCEC\|endometrium	p.T304A (No)	GDSC	Sorafenib	24.754
SIDM01045	UCEC\|endometrium	p.T304A (No)	GDSC	Cediranib	13.911
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Sunitinib	8.4676
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Sorafenib	9.214
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Imatinib	18.1666
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Dasatinib	0.1532
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Pazopanib	46.6575
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Cabozantinib	16.496
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Linifanib	10.0196
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Masitinib	18.4367
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Amuvatinib	179.3907
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	OSI-930	84.0932
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Axitinib	12.1378
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Motesanib	14.9315
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Dasatinib	0.3532
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Sorafenib	14.077
SIDM00056	THCA\|thyroid	p.A895E (No)	GDSC	Cediranib	5.6715
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	Pazopanib	12.1881
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	Cabozantinib	127.0251
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	Linifanib	29.1021
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	Masitinib	568.4015
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	Amuvatinib	2.7216
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	OSI-930	23.6345
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	Axitinib	9.4805
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	Motesanib	12.6499
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	Axitinib	47.424
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	Dasatinib	5.0056
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	Sorafenib	11.096
SIDM00630	BRCA\|breast	p.K626R (No)	GDSC	Cediranib	5.1084
SIDM00217	COREAD\|large_intestine	p.G265S (No)	GDSC	Cabozantinib	12.0756
SIDM00217	COREAD\|large_intestine	p.G265S (No)	GDSC	Linifanib	18.1376
SIDM00217	COREAD\|large_intestine	p.G265S (No)	GDSC	Masitinib	29.5935
SIDM00217	COREAD\|large_intestine	p.G265S (No)	GDSC	Amuvatinib	59.7561
SIDM00217	COREAD\|large_intestine	p.G265S (No)	GDSC	OSI-930	229.9967
SIDM00216	COREAD\|large_intestine	p.A895T (No)	GDSC	Cabozantinib	6.0987
SIDM00216	COREAD\|large_intestine	p.A895T (No)	GDSC	Linifanib	6.5206
SIDM00216	COREAD\|large_intestine	p.A895T (No)	GDSC	Masitinib	2.9989
SIDM00216	COREAD\|large_intestine	p.A895T (No)	GDSC	Amuvatinib	0.8311
SIDM00216	COREAD\|large_intestine	p.A895T (No)	GDSC	OSI-930	83.363
SIDM00216	COREAD\|large_intestine	p.A895T (No)	GDSC	Dasatinib	11.384
SIDM00216	COREAD\|large_intestine	p.A895T (No)	GDSC	Sorafenib	7.7286
SIDM00216	COREAD\|large_intestine	p.A895T (No)	GDSC	Cediranib	4.8238
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Sunitinib	81.4875
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Sorafenib	22.9832
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Imatinib	21.249
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Dasatinib	8.5377
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Pazopanib	99.8015
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Cabozantinib	5.0586
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Linifanib	14.5364
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Masitinib	24.1337
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Amuvatinib	2.5753
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	OSI-930	101.8237
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Axitinib	20.5891
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Motesanib	4.7836
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Dasatinib	43.11
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Sorafenib	6.7916
SIDM00492	GBM\|glioma	p.D910Y (No)	GDSC	Cediranib	9.9431
SIDM00396	LAML\|acute_myeloid_leukaemia	p.T520S (No)	GDSC	Sunitinib	1.4723
SIDM00396	LAML\|acute_myeloid_leukaemia	p.T520S (No)	GDSC	Sorafenib	1.9362
SIDM00396	LAML\|acute_myeloid_leukaemia	p.T520S (No)	GDSC	Imatinib	7.473
SIDM00396	LAML\|acute_myeloid_leukaemia	p.T520S (No)	GDSC	Dasatinib	2.2048
SIDM00396	LAML\|acute_myeloid_leukaemia	p.T520S (No)	GDSC	Pazopanib	23.4407
SIDM00396	LAML\|acute_myeloid_leukaemia	p.T520S (No)	GDSC	Cabozantinib	2.345
SIDM00396	LAML\|acute_myeloid_leukaemia	p.T520S (No)	GDSC	Linifanib	3.7764
SIDM00396	LAML\|acute_myeloid_leukaemia	p.T520S (No)	GDSC	Masitinib	14.5908
SIDM00396	LAML\|acute_myeloid_leukaemia	p.T520S (No)	GDSC	Amuvatinib	14.3393
SIDM00396	LAML\|acute_myeloid_leukaemia	p.T520S (No)	GDSC	OSI-930	3.0588
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Sunitinib	189.499
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Sorafenib	61.3342
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Imatinib	51.6867
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Dasatinib	34.4884
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Pazopanib	234.9693
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Cabozantinib	55.7164
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Linifanib	26.1518
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Masitinib	38.2671
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Amuvatinib	29.2756
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	OSI-930	31.3377
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Axitinib	50.4847
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Motesanib	57.5889
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Dasatinib	11.536
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Sorafenib	7.9982
SIDM00282	COREAD\|large_intestine	p.M882V (No)	GDSC	Cediranib	11.404
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Sunitinib	8.7914
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Sorafenib	4.1347
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Imatinib	17.1814
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Dasatinib	2.8208
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Pazopanib	48.6215
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Cabozantinib	49.3411
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Linifanib	11.4254
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Masitinib	188.7975
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Amuvatinib	175.0868
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	OSI-930	42.0738
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Axitinib	3.2277
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Motesanib	14.3013
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Dasatinib	4.1606
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Sorafenib	5.4855
SIDM00888	MB\|medulloblastoma	p.D737H (No)	GDSC	Cediranib	2.1185
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Sunitinib	8.392
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Sorafenib	7.1341
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Imatinib	21.2623
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Dasatinib	8.4007
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Pazopanib	11.0486
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Cabozantinib	31.9292
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Linifanib	9.5702
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Masitinib	110.4793
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Amuvatinib	14.0745
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	OSI-930	60.0187
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Axitinib	9.7763
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Motesanib	15.6556
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Dasatinib	17.196
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Sorafenib	5.2554
SIDM00543	SKCM\|melanoma	p.N655S (No)	GDSC	Cediranib	6.6078
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M535T (No)	GDSC	Pazopanib	117.5085
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M535T (No)	GDSC	Cabozantinib	45.985
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M535T (No)	GDSC	Linifanib	18.337
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M535T (No)	GDSC	Masitinib	87.5893
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M535T (No)	GDSC	Amuvatinib	355.9891
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M535T (No)	GDSC	OSI-930	185.6795
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M535T (No)	GDSC	Motesanib	18.2532
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M535T (No)	GDSC	Dasatinib	3.6591
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M535T (No)	GDSC	Sorafenib	14.527
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M535T (No)	GDSC	Cediranib	11.147
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Sunitinib	5.9236
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Sorafenib	3.764
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Imatinib	16.4171
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Dasatinib	2.1703
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Pazopanib	49.5126
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Cabozantinib	7.3542
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Linifanib	6.3611
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Masitinib	17.4328
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Amuvatinib	56.7238
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	OSI-930	29.5236
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Axitinib	2.2002
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Motesanib	6.1272
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Dasatinib	17.117
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Sorafenib	6.9336
SIDM00324	NB\|neuroblastoma	p.Q515K (No)	GDSC	Cediranib	6.705
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Sunitinib	4.3538
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Sorafenib	4.3968
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Imatinib	9.5067
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Dasatinib	6.3362
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Pazopanib	20.1605
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Cabozantinib	11.4291
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Linifanib	9.6852
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Masitinib	20.294
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Amuvatinib	55.7719
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	OSI-930	8.5591
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Axitinib	4.3721
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Motesanib	16.2033
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Dasatinib	65.684
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Sorafenib	13.447
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.G676D (No)	GDSC	Cediranib	31.636
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Sunitinib	37.6015
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Sorafenib	10.9707
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Imatinib	13.2216
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Dasatinib	5.4109
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Pazopanib	17.9935
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Cabozantinib	3.917
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Linifanib	6.681
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Masitinib	15.2674
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Amuvatinib	12.9922
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	OSI-930	35.0148
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Axitinib	8.9895
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Motesanib	10.915
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Dasatinib	10.402
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Sorafenib	4.0487
SIDM00427	UNCLASSIFIED\|rhabdomyosarcoma	p.R55W (No)	GDSC	Cediranib	6.1508
SIDM00789	COREAD\|large_intestine	p.R135H (No)	GDSC	Pazopanib	34.0168
SIDM00789	COREAD\|large_intestine	p.R135H (No)	GDSC	Cabozantinib	14.2209
SIDM00789	COREAD\|large_intestine	p.R135H (No)	GDSC	Linifanib	9.391
SIDM00789	COREAD\|large_intestine	p.R135H (No)	GDSC	Masitinib	27.6949
SIDM00789	COREAD\|large_intestine	p.R135H (No)	GDSC	Amuvatinib	62.3459
SIDM00789	COREAD\|large_intestine	p.R135H (No)	GDSC	OSI-930	44.8961
SIDM00789	COREAD\|large_intestine	p.R135H (No)	GDSC	Axitinib	7.279
SIDM00789	COREAD\|large_intestine	p.R135H (No)	GDSC	Motesanib	12.7822
SIDM00789	COREAD\|large_intestine	p.R135H (No)	GDSC	Dasatinib	2.045
SIDM00789	COREAD\|large_intestine	p.R135H (No)	GDSC	Sorafenib	10.469
SIDM00789	COREAD\|large_intestine	p.R135H (No)	GDSC	Cediranib	6.0229
SIDM00789	COREAD\|large_intestine	p.V532I (No)	GDSC	Pazopanib	34.0168
SIDM00789	COREAD\|large_intestine	p.V532I (No)	GDSC	Cabozantinib	14.2209
SIDM00789	COREAD\|large_intestine	p.V532I (No)	GDSC	Linifanib	9.391
SIDM00789	COREAD\|large_intestine	p.V532I (No)	GDSC	Masitinib	27.6949
SIDM00789	COREAD\|large_intestine	p.V532I (No)	GDSC	Amuvatinib	62.3459
SIDM00789	COREAD\|large_intestine	p.V532I (No)	GDSC	OSI-930	44.8961
SIDM00789	COREAD\|large_intestine	p.V532I (No)	GDSC	Axitinib	7.279
SIDM00789	COREAD\|large_intestine	p.V532I (No)	GDSC	Motesanib	12.7822
SIDM00789	COREAD\|large_intestine	p.V532I (No)	GDSC	Dasatinib	2.045
SIDM00789	COREAD\|large_intestine	p.V532I (No)	GDSC	Sorafenib	10.469
SIDM00789	COREAD\|large_intestine	p.V532I (No)	GDSC	Cediranib	6.0229
SIDM00789	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Pazopanib	34.0168
SIDM00789	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Cabozantinib	14.2209
SIDM00789	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Linifanib	9.391
SIDM00789	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Masitinib	27.6949
SIDM00789	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Amuvatinib	62.3459
SIDM00789	COREAD\|large_intestine	p.S967P (Yes)	GDSC	OSI-930	44.8961
SIDM00789	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Axitinib	7.279
SIDM00789	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Motesanib	12.7822
SIDM00789	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Dasatinib	2.045
SIDM00789	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Sorafenib	10.469
SIDM00789	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Cediranib	6.0229
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Sunitinib	5.3765
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Sorafenib	71.21
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Imatinib	35.605
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Dasatinib	0.1054
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Pazopanib	60.3078
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Cabozantinib	76.5191
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Linifanib	18.1725
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Masitinib	11.2367
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Amuvatinib	67.778
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	OSI-930	70.9481
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Axitinib	17.3373
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Motesanib	6.7456
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Dasatinib	2.3233
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Sorafenib	7.0505
SIDM01008	DLBC\|B_cell_lymphoma	p.G169D (No)	GDSC	Cediranib	2.1928
SIDM00114	MESO\|mesothelioma	p.V374I (No)	GDSC	Pazopanib	23.2662
SIDM00114	MESO\|mesothelioma	p.V374I (No)	GDSC	Cabozantinib	144.2481
SIDM00114	MESO\|mesothelioma	p.V374I (No)	GDSC	Linifanib	14.9174
SIDM00114	MESO\|mesothelioma	p.V374I (No)	GDSC	Masitinib	332.6703
SIDM00114	MESO\|mesothelioma	p.V374I (No)	GDSC	Amuvatinib	180.6102
SIDM00114	MESO\|mesothelioma	p.V374I (No)	GDSC	OSI-930	265.741
SIDM00114	MESO\|mesothelioma	p.V374I (No)	GDSC	Axitinib	58.0569
SIDM00114	MESO\|mesothelioma	p.V374I (No)	GDSC	Motesanib	58.0907
SIDM00114	MESO\|mesothelioma	p.V374I (No)	GDSC	Dasatinib	35.375
SIDM00114	MESO\|mesothelioma	p.V374I (No)	GDSC	Sorafenib	68.959
SIDM00114	MESO\|mesothelioma	p.V374I (No)	GDSC	Cediranib	28.532
SIDM00114	MESO\|mesothelioma	p.E885K (No)	GDSC	Pazopanib	23.2662
SIDM00114	MESO\|mesothelioma	p.E885K (No)	GDSC	Cabozantinib	144.2481
SIDM00114	MESO\|mesothelioma	p.E885K (No)	GDSC	Linifanib	14.9174
SIDM00114	MESO\|mesothelioma	p.E885K (No)	GDSC	Masitinib	332.6703
SIDM00114	MESO\|mesothelioma	p.E885K (No)	GDSC	Amuvatinib	180.6102
SIDM00114	MESO\|mesothelioma	p.E885K (No)	GDSC	OSI-930	265.741
SIDM00114	MESO\|mesothelioma	p.E885K (No)	GDSC	Axitinib	58.0569
SIDM00114	MESO\|mesothelioma	p.E885K (No)	GDSC	Motesanib	58.0907
SIDM00114	MESO\|mesothelioma	p.E885K (No)	GDSC	Dasatinib	35.375
SIDM00114	MESO\|mesothelioma	p.E885K (No)	GDSC	Sorafenib	68.959
SIDM00114	MESO\|mesothelioma	p.E885K (No)	GDSC	Cediranib	28.532
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Sunitinib	2.4087
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Sorafenib	1.4332
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Imatinib	0.1929
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Dasatinib	0.0032
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Pazopanib	26.1602
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Cabozantinib	0.6444
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Linifanib	9.6492
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Masitinib	0.3371
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Amuvatinib	11.744
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	OSI-930	3.5905
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Axitinib	0.222
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Motesanib	4.685
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Dasatinib	0.0029
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Sorafenib	2.6996
SIDM00962	LCML\|chronic_myeloid_leukaemia	p.A701S (No)	GDSC	Cediranib	3.4187
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Sunitinib	4.5847
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Sorafenib	13.9777
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Imatinib	37.1649
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Dasatinib	17.7857
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Pazopanib	14.8036
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Cabozantinib	71.6314
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Linifanib	12.5423
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Masitinib	93.7639
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Amuvatinib	72.234
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	OSI-930	56.536
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Axitinib	4.0172
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Motesanib	27.5
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Dasatinib	9.0195
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Sorafenib	16.125
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.D159N (No)	GDSC	Cediranib	8.4148
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Sunitinib	50.926
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Sorafenib	47.0414
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Imatinib	2.6048
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Dasatinib	14.9911
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Pazopanib	17.1429
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Cabozantinib	9.417
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Linifanib	8.606
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Masitinib	16.2021
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Amuvatinib	26.952
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	OSI-930	25.2572
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Axitinib	7.243
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Motesanib	8.065
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Dasatinib	1.1985
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Sorafenib	17.225
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R177H (No)	GDSC	Cediranib	5.6942
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S967P (Yes)	GDSC	Pazopanib	6.299
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S967P (Yes)	GDSC	Cabozantinib	68.3794
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S967P (Yes)	GDSC	Linifanib	9.5955
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S967P (Yes)	GDSC	Masitinib	21.5209
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S967P (Yes)	GDSC	Amuvatinib	28.6896
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S967P (Yes)	GDSC	OSI-930	24.6829
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S967P (Yes)	GDSC	Axitinib	29.6047
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S967P (Yes)	GDSC	Motesanib	25.0231
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S967P (Yes)	GDSC	Dasatinib	0.8041
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S967P (Yes)	GDSC	Sorafenib	15.089
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.S967P (Yes)	GDSC	Cediranib	7.4408
SIDM00064	LIHC\|liver	p.T446N (No)	GDSC	Pazopanib	1.7111
SIDM00064	LIHC\|liver	p.T446N (No)	GDSC	Cabozantinib	11.6273
SIDM00064	LIHC\|liver	p.T446N (No)	GDSC	Linifanib	6.6144
SIDM00064	LIHC\|liver	p.T446N (No)	GDSC	Masitinib	105.612
SIDM00064	LIHC\|liver	p.T446N (No)	GDSC	Amuvatinib	20.2095
SIDM00064	LIHC\|liver	p.T446N (No)	GDSC	OSI-930	97.757
SIDM00064	LIHC\|liver	p.T446N (No)	GDSC	Axitinib	3.3537
SIDM00064	LIHC\|liver	p.T446N (No)	GDSC	Motesanib	27.142
SIDM00064	LIHC\|liver	p.T446N (No)	GDSC	Dasatinib	1.3611
SIDM00064	LIHC\|liver	p.T446N (No)	GDSC	Sorafenib	10.973
SIDM00064	LIHC\|liver	p.T446N (No)	GDSC	Cediranib	3.9378
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Sunitinib	34.182
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Sorafenib	20.886
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Imatinib	41.4613
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Dasatinib	29.2162
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Pazopanib	170.4255
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Cabozantinib	10.2035
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Linifanib	25.1823
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Masitinib	54.8921
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Amuvatinib	117.011
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	OSI-930	98.1002
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Axitinib	115.4446
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Motesanib	68.1908
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Dasatinib	101.4
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Sorafenib	15.093
SIDM00547	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q21P (No)	GDSC	Cediranib	12.606
SIDM00834	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Pazopanib	104.5085
SIDM00834	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Cabozantinib	374.684
SIDM00834	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Linifanib	52.4861
SIDM00834	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Masitinib	109.6183
SIDM00834	COREAD\|large_intestine	p.S967P (Yes)	GDSC	OSI-930	496.6418
SIDM00834	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Axitinib	30.9746
SIDM00834	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Motesanib	19.6833
SIDM00834	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Dasatinib	58.818
SIDM00834	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Sorafenib	10.782
SIDM00834	COREAD\|large_intestine	p.S967P (Yes)	GDSC	Cediranib	10.369
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R946P (No)	GDSC	Pazopanib	19.6129
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R946P (No)	GDSC	Cabozantinib	51.1254
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R946P (No)	GDSC	Linifanib	24.6252
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R946P (No)	GDSC	Masitinib	99.0645
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R946P (No)	GDSC	Amuvatinib	142.8871
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R946P (No)	GDSC	OSI-930	102.789
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R946P (No)	GDSC	Axitinib	47.5102
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R946P (No)	GDSC	Motesanib	21.4873
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R946P (No)	GDSC	Dasatinib	36.682
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R946P (No)	GDSC	Sorafenib	10.611
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.R946P (No)	GDSC	Cediranib	18.416
SIDM01005	LAML\|acute_myeloid_leukaemia	p.N822K (No)	GDSC	Sunitinib	35.55
SIDM01005	LAML\|acute_myeloid_leukaemia	p.N822K (No)	GDSC	Sorafenib	40.2854
SIDM01005	LAML\|acute_myeloid_leukaemia	p.N822K (No)	GDSC	Imatinib	23.4979
SIDM01005	LAML\|acute_myeloid_leukaemia	p.N822K (No)	GDSC	Dasatinib	12.8718
SIDM01005	LAML\|acute_myeloid_leukaemia	p.N822K (No)	GDSC	Linifanib	0.0167
SIDM01005	LAML\|acute_myeloid_leukaemia	p.N822K (No)	GDSC	Masitinib	0.1019
SIDM01005	LAML\|acute_myeloid_leukaemia	p.N822K (No)	GDSC	Amuvatinib	1.2923
SIDM01005	LAML\|acute_myeloid_leukaemia	p.N822K (No)	GDSC	OSI-930	0.0497
SIDM01005	LAML\|acute_myeloid_leukaemia	p.N822K (No)	GDSC	Axitinib	0.0145
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.D910Y (No)	GDSC	Pazopanib	1.6216
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.D910Y (No)	GDSC	Cabozantinib	5.495
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.D910Y (No)	GDSC	Linifanib	3.5108
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.D910Y (No)	GDSC	Masitinib	4.6895
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.D910Y (No)	GDSC	Amuvatinib	7.5776
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.D910Y (No)	GDSC	OSI-930	7.1509
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.D910Y (No)	GDSC	Axitinib	1.7358
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.D910Y (No)	GDSC	Motesanib	13.5201
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.D910Y (No)	GDSC	Dasatinib	2.1865
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.D910Y (No)	GDSC	Sorafenib	10.492
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.D910Y (No)	GDSC	Cediranib	2.7933
SIDM00537	COREAD\|large_intestine	p.Y125H (No)	GDSC	Pazopanib	34.5022
SIDM00537	COREAD\|large_intestine	p.Y125H (No)	GDSC	Cabozantinib	8.3183
SIDM00537	COREAD\|large_intestine	p.Y125H (No)	GDSC	Linifanib	0.9776
SIDM00537	COREAD\|large_intestine	p.Y125H (No)	GDSC	Masitinib	14.0813
SIDM00537	COREAD\|large_intestine	p.Y125H (No)	GDSC	Amuvatinib	37.1311
SIDM00537	COREAD\|large_intestine	p.Y125H (No)	GDSC	OSI-930	22.8888
SIDM00537	COREAD\|large_intestine	p.Y125H (No)	GDSC	Axitinib	4.497
SIDM00537	COREAD\|large_intestine	p.Y125H (No)	GDSC	Motesanib	9.6673
SIDM00537	COREAD\|large_intestine	p.Y125H (No)	GDSC	Dasatinib	9.6455
SIDM00537	COREAD\|large_intestine	p.Y125H (No)	GDSC	Sorafenib	6.3081
SIDM00537	COREAD\|large_intestine	p.Y125H (No)	GDSC	Cediranib	6.2083
SIDM00537	COREAD\|large_intestine	p.T488M (No)	GDSC	Pazopanib	34.5022
SIDM00537	COREAD\|large_intestine	p.T488M (No)	GDSC	Cabozantinib	8.3183
SIDM00537	COREAD\|large_intestine	p.T488M (No)	GDSC	Linifanib	0.9776
SIDM00537	COREAD\|large_intestine	p.T488M (No)	GDSC	Masitinib	14.0813
SIDM00537	COREAD\|large_intestine	p.T488M (No)	GDSC	Amuvatinib	37.1311
SIDM00537	COREAD\|large_intestine	p.T488M (No)	GDSC	OSI-930	22.8888
SIDM00537	COREAD\|large_intestine	p.T488M (No)	GDSC	Axitinib	4.497
SIDM00537	COREAD\|large_intestine	p.T488M (No)	GDSC	Motesanib	9.6673
SIDM00537	COREAD\|large_intestine	p.T488M (No)	GDSC	Dasatinib	9.6455
SIDM00537	COREAD\|large_intestine	p.T488M (No)	GDSC	Sorafenib	6.3081
SIDM00537	COREAD\|large_intestine	p.T488M (No)	GDSC	Cediranib	6.2083
SIDM01027	ESCA\|oesophagus	p.T232M (No)	GDSC	Pazopanib	51.4498
SIDM01027	ESCA\|oesophagus	p.T232M (No)	GDSC	Cabozantinib	1.9352
SIDM01027	ESCA\|oesophagus	p.T232M (No)	GDSC	Linifanib	10.4698
SIDM01027	ESCA\|oesophagus	p.T232M (No)	GDSC	Masitinib	20.7073
SIDM01027	ESCA\|oesophagus	p.T232M (No)	GDSC	Amuvatinib	78.4725
SIDM01027	ESCA\|oesophagus	p.T232M (No)	GDSC	OSI-930	115.1369
SIDM01027	ESCA\|oesophagus	p.T232M (No)	GDSC	Axitinib	10.0793
SIDM01027	ESCA\|oesophagus	p.T232M (No)	GDSC	Motesanib	12.2556
SIDM01027	ESCA\|oesophagus	p.T232M (No)	GDSC	Dasatinib	1.0105
SIDM01027	ESCA\|oesophagus	p.T232M (No)	GDSC	Sorafenib	10.51
SIDM01027	ESCA\|oesophagus	p.T232M (No)	GDSC	Cediranib	3.3639
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Sunitinib	6.4982
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Sorafenib	2.316
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Imatinib	7.8336
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Dasatinib	11.7683
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Pazopanib	166.855
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Cabozantinib	7.2585
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Linifanib	12.2157
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Masitinib	24.1003
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Amuvatinib	36.8466
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	OSI-930	88.7174
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Axitinib	21.7122
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Motesanib	7.8955
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Dasatinib	18.819
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Sorafenib	3.4718
SIDM01146	STAD\|stomach	p.P155H (No)	GDSC	Cediranib	8.7971
SIDM00193	COREAD\|large_intestine	p.K581N (No)	GDSC	Cabozantinib	133.9123
SIDM00193	COREAD\|large_intestine	p.K581N (No)	GDSC	Linifanib	15.5526
SIDM00193	COREAD\|large_intestine	p.K581N (No)	GDSC	Masitinib	156.3947
SIDM00193	COREAD\|large_intestine	p.K581N (No)	GDSC	Amuvatinib	23.513
SIDM00193	COREAD\|large_intestine	p.K581N (No)	GDSC	OSI-930	234.9928
SIDM00193	COREAD\|large_intestine	p.K581N (No)	GDSC	Axitinib	12.6981
SIDM00193	COREAD\|large_intestine	p.K581N (No)	GDSC	Motesanib	50.1977
SIDM00193	COREAD\|large_intestine	p.I920S (No)	GDSC	Cabozantinib	133.9123
SIDM00193	COREAD\|large_intestine	p.I920S (No)	GDSC	Linifanib	15.5526
SIDM00193	COREAD\|large_intestine	p.I920S (No)	GDSC	Masitinib	156.3947
SIDM00193	COREAD\|large_intestine	p.I920S (No)	GDSC	Amuvatinib	23.513
SIDM00193	COREAD\|large_intestine	p.I920S (No)	GDSC	OSI-930	234.9928
SIDM00193	COREAD\|large_intestine	p.I920S (No)	GDSC	Axitinib	12.6981
SIDM00193	COREAD\|large_intestine	p.I920S (No)	GDSC	Motesanib	50.1977
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	Sorafenib	2.2419
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	Pazopanib	102.78
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	Cabozantinib	28.7329
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	Linifanib	12.9878
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	Masitinib	51.1198
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	Amuvatinib	109.3548
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	OSI-930	76.7328
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	Axitinib	18.812
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	Motesanib	6.3211
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	Dasatinib	31.269
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	Sorafenib	7.5049
SIDM00118	COREAD\|large_intestine	p.K623N (No)	GDSC	Cediranib	5.8015

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLVHDD

Degron related mutations and impact score

Drug responses associated with KIT mutations

All proteins holding degron of LLVHDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10721	Mast/stem cell growth factor receptor Kit	LIG_APCC_ABBA_1	970:975	LLVHDD	APC,CDC20,FZR1	0.8674	More...