DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LLVHDD
Uniprot ID:
P10721
Source protein:
Mast/stem cell growth factor receptor Kit
Source gene:
KIT
Class:
LIG_APCC_ABBA_1
Location:
970:975
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8674
ASA_SCORE:
84.9
COIL:
0.7438
CONS_SCORE:
0.3991
DSS_SCORE:
0.806
HELIX:
0.0487
FCONS_SCORE:
0.8887
RIG_SCORE:
0.7658
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H973R
TCGA-CR-7402
HNSC
TCGA
LLVHDD
LIG_APCC_ABBA_1
0.8244
p.H973R
DO15727
HNSC
ICGC
LLVHDD
LIG_APCC_ABBA_1
0.8244
p.D975N
TCGA-A5-A2K3
UCEC
TCGA
LLVHDD
LIG_APCC_ABBA_1
0.6932
p.D975N
DO43899
UCEC
ICGC
LLVHDD
LIG_APCC_ABBA_1
0.6932
p.D974Y
DO228948
LICA
ICGC
LLVHDD
LIG_APCC_ABBA_1
0.6214
p.V972M
TCGA-D1-A103
UCEC
TCGA
LLVHDD
LIG_APCC_ABBA_1
0.6097
p.V972M
DO42312
UCEC
ICGC
LLVHDD
LIG_APCC_ABBA_1
0.6097
p.S967P
ACH-000970
Colon/Colorectal Cancer
CCLE
LLVHDD
LIG_APCC_ABBA_1
0.25
p.A964S
DO228380
LICA
ICGC
LLVHDD
LIG_APCC_ABBA_1
0.1667
p.A964T
ACH-001369
Ovarian Cancer
CCLE
LLVHDD
LIG_APCC_ABBA_1
0.1667
p.G961S
TCGA-24-2267
OV
TCGA
LLVHDD
LIG_APCC_ABBA_1
0.0833
p.G961S
TCGA-XK-AAIW
PRAD
TCGA
LLVHDD
LIG_APCC_ABBA_1
0.0833
p.G961S
DO29740
OV
ICGC
LLVHDD
LIG_APCC_ABBA_1
0.0833
p.G961S
DO51407
PRAD
ICGC
LLVHDD
LIG_APCC_ABBA_1
0.0833
Showing 1 to 14 of 14 entries
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Drug responses associated with KIT mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Sunitinib
15.4202
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Sorafenib
57.7181
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Imatinib
17.4625
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Dasatinib
4.9513
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Pazopanib
43.7165
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Cabozantinib
19.1626
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Linifanib
20.6562
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Masitinib
3.5505
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Amuvatinib
2.7681
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
OSI-930
28.7093
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Axitinib
4.0786
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Motesanib
40.0823
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Dasatinib
1.7886
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Sorafenib
7.1912
SIDM01259
ALL|lymphoblastic_leukemia
p.K193fs*30 (No)
GDSC
Cediranib
2.0788
SIDM01007
ALL|lymphoblastic_leukemia
p.D131N (No)
GDSC
Sunitinib
2.0565
SIDM01007
ALL|lymphoblastic_leukemia
p.D131N (No)
GDSC
Sorafenib
4.9994
SIDM01007
ALL|lymphoblastic_leukemia
p.D131N (No)
GDSC
Imatinib
8.9862
SIDM01007
ALL|lymphoblastic_leukemia
p.D131N (No)
GDSC
Dasatinib
0.899
SIDM01007
ALL|lymphoblastic_leukemia
p.D131N (No)
GDSC
Pazopanib
9.0608
SIDM01007
ALL|lymphoblastic_leukemia
p.D131N (No)
GDSC
Cabozantinib
1.7755
SIDM01007
ALL|lymphoblastic_leukemia
p.D131N (No)
GDSC
Linifanib
4.2428
SIDM01007
ALL|lymphoblastic_leukemia
p.D131N (No)
GDSC
Masitinib
8.8751
SIDM01007
ALL|lymphoblastic_leukemia
p.D131N (No)
GDSC
Amuvatinib
23.5168
SIDM01007
ALL|lymphoblastic_leukemia
p.D131N (No)
GDSC
OSI-930
10.8303
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All proteins holding degron of LLVHDD
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P10721
Mast/stem cell growth factor receptor Kit
LIG_APCC_ABBA_1
970:975
LLVHDD
APC,CDC20,FZR1
0.8674
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