DegronMD - P10916(MYL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P74S	TCGA-06-5416	GBM	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0833
p.P74S	TCGA-W3-AA1W	SKCM	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0833
p.V81A	TCGA-44-8117	LUAD	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.2778
p.L90I	TCGA-77-7141	LUSC	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.2778
p.P95T	TCGA-91-A4BC	LUAD	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1389
p.E97K	TCGA-95-7039	LUAD	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0833
p.E97K	TCGA-QB-A6FS	SKCM	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0833
p.E88D	TCGA-AP-A0LM	UCEC	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation altering degron motif	0.5647
p.P95H	TCGA-B4-5377	KIRC	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1389
p.P74T	TCGA-B5-A0K9	UCEC	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0833
p.M85V	TCGA-B5-A3FA	UCEC	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation altering degron motif	0.6097
p.F79C	TCGA-BR-8680	STAD	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.2222
p.K91N	TCGA-DA-A1HV	SKCM	TCGA	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation substituting flanking lysine	0.3611
p.K97N	DO225346	BRCA	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0833
p.T84I	DO229010	COCA	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation altering degron motif	0.5966
p.P81H	DO20229	KIRC	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.2778
p.D80E	DO228948	LICA	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation blocking phosphorylation signal	0.6944
p.D93E	DO229015	LICA	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1944
p.P94T	DO229032	LICA	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1667
p.P94T	DO229045	LICA	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1667
p.P81T	DO45422	LUAD	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.2778
p.E83K	DO23907	LUAD	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation altering degron motif	0.7022
p.E83K	DO48654	SKCM	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation altering degron motif	0.7022
p.E82K	DO231075	LUSC	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.3056
p.L76I	DO26450	LUSC	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1389
p.K97T	DO27596	LUSC	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0833
p.A88T	DO33091	PACA	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation altering degron motif	0.7139
p.A88T	SBC-3	lung	COSMIC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation altering degron motif	0.7139
p.K77N	DO37659	SKCM	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1667
p.E74D	DO43306	UCEC	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.0833
p.L86F	DO42713	UCEC	ICGC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation altering degron motif	0.6981
p.D94N	SIDM00216	Colorectal Carcinoma	GDSC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1667
p.D94N	ACH-000989	Colon/Colorectal Cancer	CCLE	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1667
p.D94N	SNU-175	large intestine	COSMIC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1667
p.I77F	SIDM00864	Cervical Carcinoma	GDSC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1667
p.I77F	ACH-001341	Cervical Cancer	CCLE	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1667
p.I77F	DoTc2-4510	cervix	COSMIC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation rewiring degron network	0.1667
p.D80N	SNU-175	large intestine	COSMIC	LTMFGE	LIG_APCC_ABBA_1	83:88	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for MYL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYL2

UniProt ID: P10916

Entrez ID: 4633

Protein name: Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYL2 in