DegronMD

Uniprot ID: P10916

Source protein: Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

Source gene: MYL2

Class: LIG_APCC_ABBA_1

Location: 83:88

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5713

ASA_SCORE: 41.0667

COIL: 0.0775

CONS_SCORE: 0.7858

DSS_SCORE: 0.2015

HELIX: 0.9185

FCONS_SCORE: 1.2338

RIG_SCORE: 0.8759

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P74S	TCGA-06-5416	GBM	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.0833
p.P74S	TCGA-W3-AA1W	SKCM	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.0833
p.V81A	TCGA-44-8117	LUAD	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.2778
p.L90I	TCGA-77-7141	LUSC	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.2778
p.P95T	TCGA-91-A4BC	LUAD	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.1389
p.E97K	TCGA-95-7039	LUAD	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.0833
p.E97K	TCGA-QB-A6FS	SKCM	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.0833
p.E88D	TCGA-AP-A0LM	UCEC	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.5647
p.P95H	TCGA-B4-5377	KIRC	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.1389
p.P74T	TCGA-B5-A0K9	UCEC	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.0833
p.M85V	TCGA-B5-A3FA	UCEC	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.6097
p.F79C	TCGA-BR-8680	STAD	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.2222
p.K91N	TCGA-DA-A1HV	SKCM	TCGA	LTMFGE	LIG_APCC_ABBA_1	0.3611
p.K97N	DO225346	BRCA	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.0833
p.T84I	DO229010	COCA	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.5966
p.P81H	DO20229	KIRC	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.2778
p.D80E	DO228948	LICA	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.6944
p.D93E	DO229015	LICA	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.1944
p.P94T	DO229032	LICA	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.1667
p.P94T	DO229045	LICA	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.1667
p.P81T	DO45422	LUAD	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.2778
p.E83K	DO23907	LUAD	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.7022
p.E83K	DO48654	SKCM	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.7022
p.E82K	DO231075	LUSC	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.3056
p.L76I	DO26450	LUSC	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.1389
p.K97T	DO27596	LUSC	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.0833
p.A88T	DO33091	PACA	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.7139
p.A88T	SBC-3	lung	COSMIC	LTMFGE	LIG_APCC_ABBA_1	0.7139
p.K77N	DO37659	SKCM	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.1667
p.E74D	DO43306	UCEC	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.0833
p.L86F	DO42713	UCEC	ICGC	LTMFGE	LIG_APCC_ABBA_1	0.6981
p.D94N	SIDM00216	Colorectal Carcinoma	GDSC	LTMFGE	LIG_APCC_ABBA_1	0.1667
p.D94N	ACH-000989	Colon/Colorectal Cancer	CCLE	LTMFGE	LIG_APCC_ABBA_1	0.1667
p.D94N	SNU-175	large_intestine	COSMIC	LTMFGE	LIG_APCC_ABBA_1	0.1667
p.I77F	SIDM00864	Cervical Carcinoma	GDSC	LTMFGE	LIG_APCC_ABBA_1	0.1667
p.I77F	ACH-001341	Cervical Cancer	CCLE	LTMFGE	LIG_APCC_ABBA_1	0.1667
p.I77F	DoTc2-4510	cervix	COSMIC	LTMFGE	LIG_APCC_ABBA_1	0.1667
p.D80N	SNU-175	large_intestine	COSMIC	LTMFGE	LIG_APCC_ABBA_1	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTMFGE

Degron related mutations and impact score

Drug responses associated with MYL2 mutations

All proteins holding degron of LTMFGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10916	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform	LIG_APCC_ABBA_1	83:88	LTMFGE	APC,CDC20,FZR1	0.5713	More...