DegronMD - P10997(IAPP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N85K	TCGA-95-7039	LUAD	TCGA	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5806
p.N85K	DO23907	LUAD	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5806
p.L87M	TCGA-95-7039	LUAD	TCGA	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5999
p.L87M	TCGA-BR-4256	STAD	TCGA	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5999
p.L87M	TCGA-D7-6522	STAD	TCGA	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5999
p.L87M	DO23907	LUAD	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5999
p.L87M	DO38384	STAD	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5999
p.L87M	DO38743	STAD	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5999
p.P88T	TCGA-BR-4184	STAD	TCGA	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5919
p.P88T	DO38328	STAD	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5919
p.R73H	DO227802	COCA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.1389
p.L87V	DO233671	GACA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5654
p.L87V	DO33432	PACA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5654
p.V78F	DO228976	LICA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.2778
p.E82D	DO228986	LICA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5647
p.G71S	DO229459	SKCA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation rewiring degron network	0.0833
p.N85S	SIDM00454	Rhabdomyosarcoma	GDSC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5958
p.N85S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	KREPLNYLP	DEG_APCC_DBOX_1	80:88	Mutation altering degron motif	0.5958

Kaplan plot for IAPP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IAPP

UniProt ID: P10997

Entrez ID: 3375

Protein name: Islet amyloid polypeptide (Amylin) (Diabetes-associated peptide) (DAP) (Insulinoma amyloid peptide)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IAPP in