DegronMD

Uniprot ID: P10997

Source protein: Islet amyloid polypeptide

Source gene: IAPP

Class: DEG_APCC_DBOX_1

Location: 80:88

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7729

ASA_SCORE: 103.3

COIL: 0.7243

CONS_SCORE: 0.4427

DSS_SCORE: 0.5177

HELIX: 0.2514

FCONS_SCORE: 0.664

RIG_SCORE: 0.8287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N85K	TCGA-95-7039	LUAD	TCGA	KREPLNYLP	DEG_APCC_DBOX_1	0.5806
p.N85K	DO23907	LUAD	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	0.5806
p.L87M	TCGA-95-7039	LUAD	TCGA	KREPLNYLP	DEG_APCC_DBOX_1	0.5999
p.L87M	TCGA-BR-4256	STAD	TCGA	KREPLNYLP	DEG_APCC_DBOX_1	0.5999
p.L87M	TCGA-D7-6522	STAD	TCGA	KREPLNYLP	DEG_APCC_DBOX_1	0.5999
p.L87M	DO23907	LUAD	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	0.5999
p.L87M	DO38384	STAD	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	0.5999
p.L87M	DO38743	STAD	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	0.5999
p.P88T	TCGA-BR-4184	STAD	TCGA	KREPLNYLP	DEG_APCC_DBOX_1	0.5919
p.P88T	DO38328	STAD	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	0.5919
p.R73H	DO227802	COCA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	0.1389
p.L87V	DO233671	GACA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	0.5654
p.L87V	DO33432	PACA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	0.5654
p.V78F	DO228976	LICA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	0.2778
p.E82D	DO228986	LICA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	0.5647
p.G71S	DO229459	SKCA	ICGC	KREPLNYLP	DEG_APCC_DBOX_1	0.0833
p.N85S	SIDM00454	Rhabdomyosarcoma	GDSC	KREPLNYLP	DEG_APCC_DBOX_1	0.5958
p.N85S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	KREPLNYLP	DEG_APCC_DBOX_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10997	Islet amyloid polypeptide	DEG_APCC_DBOX_1	80:88	KREPLNYLP	APC,CDC20,FZR1	0.7729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons