DegronMD - P11172(UMPS)

UMPS

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P234A	TCGA-24-1422	OV	TCGA	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.6392
p.R230C	TCGA-2W-A8YY	CESC	TCGA	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.8301
p.P234H	TCGA-BG-A222	UCEC	TCGA	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.6583
p.S241L	TCGA-E6-A1LX	UCEC	TCGA	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation blocking phosphorylation signal	0.6667
p.P238L	TCGA-EE-A2ML	SKCM	TCGA	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.3056
p.L235V	DO219024	BLCA	ICGC	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.6765
p.M230L	DO23590	LUAD	ICGC	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.711
p.M230K	DO48188	UCEC	ICGC	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.8062
p.A245T	DO41235	UCEC	ICGC	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation rewiring degron network	0.1111
p.R235M	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.7521
p.R235M	ACH-000826	Lung Cancer	CCLE	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.7521
p.R235M	CAL-12T	lung	COSMIC	ARAELPRIH	DEG_APCC_DBOX_1	229:237	Mutation altering degron motif	0.7521

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*NOTE: the Kaplan plots were collected from OncoLnc