DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ARAELPRIH
Uniprot ID:
P11172
Source protein:
Uridine 5'-monophosphate synthase
Source gene:
UMPS
Class:
DEG_APCC_DBOX_1
Location:
229:237
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5114
ASA_SCORE:
75.6
COIL:
0.743
CONS_SCORE:
0.2858
DSS_SCORE:
0.2638
HELIX:
0.2373
FCONS_SCORE:
1.0769
RIG_SCORE:
0.7424
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P234A
TCGA-24-1422
OV
TCGA
ARAELPRIH
DEG_APCC_DBOX_1
0.6392
p.R230C
TCGA-2W-A8YY
CESC
TCGA
ARAELPRIH
DEG_APCC_DBOX_1
0.8301
p.P234H
TCGA-BG-A222
UCEC
TCGA
ARAELPRIH
DEG_APCC_DBOX_1
0.6583
p.S241L
TCGA-E6-A1LX
UCEC
TCGA
ARAELPRIH
DEG_APCC_DBOX_1
0.6667
p.P238L
TCGA-EE-A2ML
SKCM
TCGA
ARAELPRIH
DEG_APCC_DBOX_1
0.3056
p.L235V
DO219024
BLCA
ICGC
ARAELPRIH
DEG_APCC_DBOX_1
0.6765
p.M230L
DO23590
LUAD
ICGC
ARAELPRIH
DEG_APCC_DBOX_1
0.711
p.M230K
DO48188
UCEC
ICGC
ARAELPRIH
DEG_APCC_DBOX_1
0.8062
p.A245T
DO41235
UCEC
ICGC
ARAELPRIH
DEG_APCC_DBOX_1
0.1111
p.R235M
SIDM00939
Non-Small Cell Lung Carcinoma
GDSC
ARAELPRIH
DEG_APCC_DBOX_1
0.7521
p.R235M
ACH-000826
Lung Cancer
CCLE
ARAELPRIH
DEG_APCC_DBOX_1
0.7521
p.R235M
CAL-12T
lung
COSMIC
ARAELPRIH
DEG_APCC_DBOX_1
0.7521
Drug responses associated with UMPS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARAELPRIH
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P11172
Uridine 5'-monophosphate synthase
DEG_APCC_DBOX_1
229:237
ARAELPRIH
APC,CDC20,FZR1
0.5114
More...