DegronMD - P11182(DBT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P154L	TCGA-CQ-A4CH	HNSC	TCGA	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation altering degron motif	0.7582
p.P154L	DO49990	HNSC	ICGC	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation altering degron motif	0.7582
p.T140M	TCGA-CS-6670	LGG	TCGA	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.0556
p.T140M	DO22161	LGG	ICGC	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.0556
p.E152D	TCGA-DF-A2KU	UCEC	TCGA	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation altering degron motif	0.5647
p.E152D	DO223286	UCEC	ICGC	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation altering degron motif	0.5647
p.E152G	TCGA-E6-A1LX	UCEC	TCGA	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation altering degron motif	0.6087
p.E152G	DO41020	UCEC	ICGC	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation altering degron motif	0.6087
p.H158Y	DO224557	BRCA	ICGC	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.3056
p.H158Y	DO1003	BRCA	ICGC	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.3056
p.T140K	DO229006	LICA	ICGC	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.0556
p.T162A	SIDM00878	Breast Carcinoma	GDSC	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.1944
p.T162A	SIDM00217	Colorectal Carcinoma	GDSC	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.1944
p.T162A	ACH-000930	Breast Cancer	CCLE	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.1944
p.T162A	ACH-000999	Colon/Colorectal Cancer	CCLE	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.1944
p.T162A	HCC1569	breast	COSMIC	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.1944
p.T162A	SNU-1040	large intestine	COSMIC	VVETPAVS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.1944

Kaplan plot for DBT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DBT

UniProt ID: P11182

Entrez ID: 1629

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DBT in