DegronMD

Uniprot ID: P11182

Source protein: Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

Source gene: DBT

Class: DEG_SCF_FBW7_1

Location: 150:157

E3 ligase: FBXW7

DEGRON score: 0.9613

ASA_SCORE: 91.975

COIL: 0.9449

CONS_SCORE: 0.4833

DSS_SCORE: 0.6402

HELIX: 0.0221

FCONS_SCORE: 1.0595

RIG_SCORE: 0.6989

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P154L	TCGA-CQ-A4CH	HNSC	TCGA	VVETPAVS	DEG_SCF_FBW7_1	0.7582
p.P154L	DO49990	HNSC	ICGC	VVETPAVS	DEG_SCF_FBW7_1	0.7582
p.T140M	TCGA-CS-6670	LGG	TCGA	VVETPAVS	DEG_SCF_FBW7_1	0.0556
p.T140M	DO22161	LGG	ICGC	VVETPAVS	DEG_SCF_FBW7_1	0.0556
p.E152D	TCGA-DF-A2KU	UCEC	TCGA	VVETPAVS	DEG_SCF_FBW7_1	0.5647
p.E152D	DO223286	UCEC	ICGC	VVETPAVS	DEG_SCF_FBW7_1	0.5647
p.E152G	TCGA-E6-A1LX	UCEC	TCGA	VVETPAVS	DEG_SCF_FBW7_1	0.6087
p.E152G	DO41020	UCEC	ICGC	VVETPAVS	DEG_SCF_FBW7_1	0.6087
p.H158Y	DO224557	BRCA	ICGC	VVETPAVS	DEG_SCF_FBW7_1	0.3056
p.H158Y	DO1003	BRCA	ICGC	VVETPAVS	DEG_SCF_FBW7_1	0.3056
p.T140K	DO229006	LICA	ICGC	VVETPAVS	DEG_SCF_FBW7_1	0.0556
p.T162A	SIDM00878	Breast Carcinoma	GDSC	VVETPAVS	DEG_SCF_FBW7_1	0.1944
p.T162A	SIDM00217	Colorectal Carcinoma	GDSC	VVETPAVS	DEG_SCF_FBW7_1	0.1944
p.T162A	ACH-000930	Breast Cancer	CCLE	VVETPAVS	DEG_SCF_FBW7_1	0.1944
p.T162A	ACH-000999	Colon/Colorectal Cancer	CCLE	VVETPAVS	DEG_SCF_FBW7_1	0.1944
p.T162A	HCC1569	breast	COSMIC	VVETPAVS	DEG_SCF_FBW7_1	0.1944
p.T162A	SNU-1040	large_intestine	COSMIC	VVETPAVS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11182	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial	DEG_SCF_FBW7_1	150:157	VVETPAVS	FBXW7	0.9613	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons