DegronMD - P11215(ITGAM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R689H	TCGA-B5-A3FA	UCEC	TCGA	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.2778
p.R689H	SIDM00422	Hodgkin's Lymphoma	GDSC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.2778
p.R689H	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.2778
p.G683S	DO227900	COCA	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.6993
p.V690I	DO50330	ESAD	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.25
p.S687F	DO220908	MELA	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.7982
p.S687F	DO222714	MELA	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.7982
p.R684L	DO234063	THCA	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.7316
p.R688H	DO52402	UCEC	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.3056
p.R688H	ACH-001203	Lymphoma	CCLE	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.3056
p.R688H	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.3056
p.S697R	DO41235	UCEC	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.0556
p.P686S	SIDM00189	Melanoma	GDSC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.6752
p.P686S	CP67-MEL	skin	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.6752
p.A690S	SIDM00120	Prostate Carcinoma	GDSC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.25
p.A690S	DU-145	prostate	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.25
p.R689S	SIDM00945	Colorectal Carcinoma	GDSC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.2778
p.R689S	CL-34	large intestine	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.2778
p.H687L	SIDM00889	Cervical Carcinoma	GDSC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.7313
p.H687L	ACH-001333	Cervical Cancer	CCLE	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.7313
p.H687L	C-33-A	cervix	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.7313
p.R688S	ACH-000895	Colon/Colorectal Cancer	CCLE	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.3056
p.R688S	CL-34	large intestine	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.3056
p.A689S	ACH-000979	Prostate Cancer	CCLE	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.2778
p.A689S	DU-145	prostate	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation rewiring degron network	0.2778
p.P685S	ACH-002098	Skin Cancer	CCLE	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.5641
p.P685S	CP67-MEL	skin	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.5641
p.H686L	C-33-A	cervix	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	681:687	Mutation altering degron motif	0.6202

Kaplan plot for ITGAM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITGAM

UniProt ID: P11215

Entrez ID: 3684

Protein name: Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITGAM in