DegronMD

Uniprot ID: P11215

Source protein: Integrin alpha-M

Source gene: ITGAM

Class: DEG_SCF_TRCP1_1

Location: 681:687

E3 ligase: BTRC

DEGRON score: 0.9482

ASA_SCORE: 67

COIL: 0.7294

CONS_SCORE: 0.4478

DSS_SCORE: 0.4005

HELIX: 0.0137

FCONS_SCORE: 0.8396

RIG_SCORE: 0.6727

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R689H	TCGA-B5-A3FA	UCEC	TCGA	DSGRPHS	DEG_SCF_TRCP1_1	0.2778
p.R689H	SIDM00422	Hodgkin's Lymphoma	GDSC	DSGRPHS	DEG_SCF_TRCP1_1	0.2778
p.R689H	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	0.2778
p.G683S	DO227900	COCA	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	0.6993
p.V690I	DO50330	ESAD	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	0.25
p.S687F	DO220908	MELA	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	0.7982
p.S687F	DO222714	MELA	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	0.7982
p.R684L	DO234063	THCA	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	0.7316
p.R688H	DO52402	UCEC	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	0.3056
p.R688H	ACH-001203	Lymphoma	CCLE	DSGRPHS	DEG_SCF_TRCP1_1	0.3056
p.R688H	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	0.3056
p.S697R	DO41235	UCEC	ICGC	DSGRPHS	DEG_SCF_TRCP1_1	0.0556
p.P686S	SIDM00189	Melanoma	GDSC	DSGRPHS	DEG_SCF_TRCP1_1	0.6752
p.P686S	CP67-MEL	skin	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	0.6752
p.A690S	SIDM00120	Prostate Carcinoma	GDSC	DSGRPHS	DEG_SCF_TRCP1_1	0.25
p.A690S	DU-145	prostate	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	0.25
p.R689S	SIDM00945	Colorectal Carcinoma	GDSC	DSGRPHS	DEG_SCF_TRCP1_1	0.2778
p.R689S	CL-34	large_intestine	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	0.2778
p.H687L	SIDM00889	Cervical Carcinoma	GDSC	DSGRPHS	DEG_SCF_TRCP1_1	0.7313
p.H687L	ACH-001333	Cervical Cancer	CCLE	DSGRPHS	DEG_SCF_TRCP1_1	0.7313
p.H687L	C-33-A	cervix	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	0.7313
p.R688S	ACH-000895	Colon/Colorectal Cancer	CCLE	DSGRPHS	DEG_SCF_TRCP1_1	0.3056
p.R688S	CL-34	large_intestine	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	0.3056
p.A689S	ACH-000979	Prostate Cancer	CCLE	DSGRPHS	DEG_SCF_TRCP1_1	0.2778
p.A689S	DU-145	prostate	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	0.2778
p.P685S	ACH-002098	Skin Cancer	CCLE	DSGRPHS	DEG_SCF_TRCP1_1	0.5641
p.P685S	CP67-MEL	skin	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	0.5641
p.H686L	C-33-A	cervix	COSMIC	DSGRPHS	DEG_SCF_TRCP1_1	0.6202

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRPHS

Degron related mutations and impact score

Drug responses associated with ITGAM mutations

All proteins holding degron of DSGRPHS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11215	Integrin alpha-M	DEG_SCF_TRCP1_1	681:687	DSGRPHS	BTRC	0.9482	More...