DegronMD - P11387(TOP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E403Q	TCGA-24-1422	OV	TCGA	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.1111
p.E403Q	DO28863	OV	ICGC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.1111
p.A96S	TCGA-24-1469	OV	TCGA	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.0833
p.A96S	DO32626	OV	ICGC	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.0833
p.I377V	TCGA-95-7039	LUAD	TCGA	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.0556
p.I377V	DO23907	LUAD	ICGC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.0556
p.R95Q	TCGA-A5-A2K5	UCEC	TCGA	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.0556
p.R95Q	DO41379	UCEC	ICGC	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.0556
p.R405Q	TCGA-A6-5659	COAD	TCGA	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.0556
p.R405Q	DO9860	COAD	ICGC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.0556
p.R405W	TCGA-AJ-A3OJ	UCEC	TCGA	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.0556
p.R405W	DO42753	UCEC	ICGC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.0556
p.R405W	SIDM00217	Colorectal Carcinoma	GDSC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.0556
p.R405W	ACH-000999	Colon/Colorectal Cancer	CCLE	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.0556
p.R405W	SNU-1040	large intestine	COSMIC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.0556
p.Q115H	TCGA-BT-A0YX	BLCA	TCGA	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.1667
p.Q115H	DO516	BLCA	ICGC	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.1667
p.D118Y	TCGA-DJ-A2QB	THCA	TCGA	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.0833
p.D118Y	DO39421	THCA	ICGC	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.0833
p.F110L	TCGA-EO-A22U	UCEC	TCGA	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.3056
p.F110L	DO43755	UCEC	ICGC	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.3056
p.E380K	TCGA-FI-A2D5	UCEC	TCGA	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.1389
p.E380K	DO41331	UCEC	ICGC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.1389
p.P393S	TCGA-FW-A3R5	SKCM	TCGA	SKDAKVPSP	DEG_COP1_1	387:395	Mutation altering degron motif	0.6752
p.P393S	DO37406	SKCM	ICGC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation altering degron motif	0.6752
p.P397S	TCGA-WE-A8K4	SKCM	TCGA	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.2778
p.P397S	DO51281	SKCM	ICGC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.2778
p.G398E	DO228288	LICA	ICGC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.25
p.K106E	DO228241	LICA	ICGC	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation altering degron motif	0.7022
p.G98W	DO228948	LICA	ICGC	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.1389
p.A390S	DO228976	LICA	ICGC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation altering degron motif	0.6477
p.VR404VW	DO222898	MELA	ICGC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0
p.E380V	DO46783	PAEN	ICGC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.1389
p.S111P	SIDM00954	Breast Carcinoma	GDSC	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation blocking phosphorylation signal	0.7222
p.S111P	ACH-001820	Breast Cancer	CCLE	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation blocking phosphorylation signal	0.7222
p.S111P	COLO-824	breast	COSMIC	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation blocking phosphorylation signal	0.7222
p.G109V	SIDM00999	Bladder Carcinoma	GDSC	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation altering degron motif	0.6421
p.G109V	ACH-000973	Bladder Cancer	CCLE	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation altering degron motif	0.6421
p.G109V	639-V	urinary tract	COSMIC	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation altering degron motif	0.6421
p.P397A	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.2778
p.P397A	ACH-002253	Lymphoma	CCLE	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.2778
p.P397A	JSC-1	haematopoietic and lymphoid tissue	COSMIC	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.2778
p.I102L	ACH-000993	Endometrial/Uterine Cancer	CCLE	EKENG	DEG_APCC_KENBOX_2	105:109	Mutation rewiring degron network	0.25
p.I382R	ACH-000993	Endometrial/Uterine Cancer	CCLE	SKDAKVPSP	DEG_COP1_1	387:395	Mutation rewiring degron network	0.1944

Kaplan plot for TOP1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOP1

UniProt ID: P11387

Entrez ID: 7150

Protein name: DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TOP1 in