DegronMD

Uniprot ID: P11387

Source protein: DNA topoisomerase 1

Source gene: TOP1

Class: DEG_COP1_1

Location: 387:395

E3 ligase: COP1

DEGRON score: 0.9888

ASA_SCORE: 69.5333

COIL: 0.8752

CONS_SCORE: 0.6802

DSS_SCORE: 0.5413

HELIX: 0.0357

FCONS_SCORE: 0.8699

RIG_SCORE: 0.6677

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E403Q	TCGA-24-1422	OV	TCGA	SKDAKVPSP	DEG_COP1_1	0.1111
p.E403Q	DO28863	OV	ICGC	SKDAKVPSP	DEG_COP1_1	0.1111
p.I377V	TCGA-95-7039	LUAD	TCGA	SKDAKVPSP	DEG_COP1_1	0.0556
p.I377V	DO23907	LUAD	ICGC	SKDAKVPSP	DEG_COP1_1	0.0556
p.R405Q	TCGA-A6-5659	COAD	TCGA	SKDAKVPSP	DEG_COP1_1	0.0556
p.R405Q	DO9860	COAD	ICGC	SKDAKVPSP	DEG_COP1_1	0.0556
p.R405W	TCGA-AJ-A3OJ	UCEC	TCGA	SKDAKVPSP	DEG_COP1_1	0.0556
p.R405W	DO42753	UCEC	ICGC	SKDAKVPSP	DEG_COP1_1	0.0556
p.R405W	SIDM00217	Colorectal Carcinoma	GDSC	SKDAKVPSP	DEG_COP1_1	0.0556
p.R405W	ACH-000999	Colon/Colorectal Cancer	CCLE	SKDAKVPSP	DEG_COP1_1	0.0556
p.R405W	SNU-1040	large_intestine	COSMIC	SKDAKVPSP	DEG_COP1_1	0.0556
p.E380K	TCGA-FI-A2D5	UCEC	TCGA	SKDAKVPSP	DEG_COP1_1	0.1389
p.E380K	DO41331	UCEC	ICGC	SKDAKVPSP	DEG_COP1_1	0.1389
p.P393S	TCGA-FW-A3R5	SKCM	TCGA	SKDAKVPSP	DEG_COP1_1	0.6752
p.P393S	DO37406	SKCM	ICGC	SKDAKVPSP	DEG_COP1_1	0.6752
p.P397S	TCGA-WE-A8K4	SKCM	TCGA	SKDAKVPSP	DEG_COP1_1	0.2778
p.P397S	DO51281	SKCM	ICGC	SKDAKVPSP	DEG_COP1_1	0.2778
p.G398E	DO228288	LICA	ICGC	SKDAKVPSP	DEG_COP1_1	0.25
p.A390S	DO228976	LICA	ICGC	SKDAKVPSP	DEG_COP1_1	0.6477
p.VR404VW	DO222898	MELA	ICGC	SKDAKVPSP	DEG_COP1_1	0
p.E380V	DO46783	PAEN	ICGC	SKDAKVPSP	DEG_COP1_1	0.1389
p.P397A	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	SKDAKVPSP	DEG_COP1_1	0.2778
p.P397A	ACH-002253	Lymphoma	CCLE	SKDAKVPSP	DEG_COP1_1	0.2778
p.P397A	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	SKDAKVPSP	DEG_COP1_1	0.2778
p.I382R	ACH-000993	Endometrial/Uterine Cancer	CCLE	SKDAKVPSP	DEG_COP1_1	0.1944

Drug responses associated with TOP1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000996	Endometrial/Uterine Cancer	p.E63D (No)	CCLE	Irinotecan	2.3452
ACH-000996	Endometrial/Uterine Cancer	p.E63D (No)	CCLE	Topotecan	2.1286
ACH-000472	Head and Neck Cancer	p.H81R (No)	CCLE	Irinotecan	0.1419
ACH-000472	Head and Neck Cancer	p.H81R (No)	CCLE	Topotecan	0.1134
ACH-000973	Bladder Cancer	p.G109V (No)	CCLE	Irinotecan	0.0696
ACH-000973	Bladder Cancer	p.G109V (No)	CCLE	Topotecan	0.0437
ACH-000996	Endometrial/Uterine Cancer	p.E166K (No)	CCLE	Irinotecan	2.3452
ACH-000996	Endometrial/Uterine Cancer	p.E166K (No)	CCLE	Topotecan	2.1286
ACH-000978	Endometrial/Uterine Cancer	p.K174fs (No)	CCLE	Irinotecan	4.7844
ACH-000978	Endometrial/Uterine Cancer	p.K174fs (No)	CCLE	Topotecan	8
ACH-000053	Lymphoma	p.K184E (No)	CCLE	Topotecan	0.6266
ACH-000397	Endometrial/Uterine Cancer	p.K202T (No)	CCLE	Irinotecan	2.1471
ACH-000397	Endometrial/Uterine Cancer	p.K202T (No)	CCLE	Topotecan	3.6082
ACH-000945	Lung Cancer	p.P235T (No)	CCLE	Topotecan	1.1974
ACH-000995	Leukemia	p.G244D (No)	CCLE	Irinotecan	0.0575
ACH-000995	Leukemia	p.G244D (No)	CCLE	Topotecan	0.0521
ACH-000980	Lung Cancer	p.T258M (No)	CCLE	Topotecan	0.0523
ACH-000389	Brain Cancer	p.A351D (No)	CCLE	Topotecan	0.511
ACH-000611	Lymphoma	p.E561K (No)	CCLE	Irinotecan	0.1156
ACH-000611	Lymphoma	p.E561K (No)	CCLE	Topotecan	0.1148
ACH-000997	Colon/Colorectal Cancer	p.M675I (No)	CCLE	Irinotecan	0.2627
ACH-000997	Colon/Colorectal Cancer	p.M675I (No)	CCLE	Topotecan	0.4025
ACH-000247	Gastric Cancer	p.E710D (No)	CCLE	Irinotecan	0.2568
ACH-000247	Gastric Cancer	p.E710D (No)	CCLE	Topotecan	0.1999
ACH-000967	Colon/Colorectal Cancer	p.I714T (No)	CCLE	Topotecan	1.2461
ACH-001199	Colon/Colorectal Cancer	p.I714T (No)	CCLE	Topotecan	0.4194
ACH-000958	Colon/Colorectal Cancer	p.W754C (No)	CCLE	Irinotecan	0.0814
ACH-000958	Colon/Colorectal Cancer	p.W754C (No)	CCLE	Topotecan	0.0976
SIDM00420	BLCA\|bladder	p.F361fs*13 (No)	GDSC	SN-38	0.0179
SIDM00420	BLCA\|bladder	p.F361fs*13 (No)	GDSC	SN-38	0.0172
SIDM00420	BLCA\|bladder	p.F361fs*13 (No)	GDSC	Camptothecin	0.5825
SIDM00420	BLCA\|bladder	p.F361fs*13 (No)	GDSC	Irinotecan	106.19
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.D528E (No)	GDSC	SN-38	0.1226
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.D528E (No)	GDSC	SN-38	0.0762
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.D528E (No)	GDSC	Camptothecin	0.3187
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.D528E (No)	GDSC	Irinotecan	32.108
SIDM00688	DLBC\|B_cell_lymphoma	p.P397A (Yes)	GDSC	SN-38	0.0016
SIDM00688	DLBC\|B_cell_lymphoma	p.P397A (Yes)	GDSC	SN-38	0.0018
SIDM00688	DLBC\|B_cell_lymphoma	p.P397A (Yes)	GDSC	Camptothecin	0.0086
SIDM00688	DLBC\|B_cell_lymphoma	p.P397A (Yes)	GDSC	Irinotecan	0.9892
SIDM01045	UCEC\|endometrium	p.P176fs*4 (No)	GDSC	SN-38	0.3308
SIDM01045	UCEC\|endometrium	p.P176fs*4 (No)	GDSC	SN-38	0.8828
SIDM01045	UCEC\|endometrium	p.P176fs*4 (No)	GDSC	Camptothecin	4.3087
SIDM01045	UCEC\|endometrium	p.P176fs*4 (No)	GDSC	Irinotecan	227.18
SIDM00145	ALL\|lymphoblastic_leukemia	p.E610K (No)	GDSC	SN-38	0.0001
SIDM00145	ALL\|lymphoblastic_leukemia	p.E610K (No)	GDSC	SN-38	0.0014
SIDM00145	ALL\|lymphoblastic_leukemia	p.E610K (No)	GDSC	Camptothecin	0.0091
SIDM00145	ALL\|lymphoblastic_leukemia	p.E610K (No)	GDSC	Irinotecan	1.0235
SIDM00145	ALL\|lymphoblastic_leukemia	p.A622T (No)	GDSC	SN-38	0.0001
SIDM00145	ALL\|lymphoblastic_leukemia	p.A622T (No)	GDSC	SN-38	0.0014
SIDM00145	ALL\|lymphoblastic_leukemia	p.A622T (No)	GDSC	Camptothecin	0.0091
SIDM00145	ALL\|lymphoblastic_leukemia	p.A622T (No)	GDSC	Irinotecan	1.0235
SIDM00454	UNCLASSIFIED\|rhabdomyosarcoma	p.N296S (No)	GDSC	SN-38	0.0002
SIDM00454	UNCLASSIFIED\|rhabdomyosarcoma	p.N296S (No)	GDSC	SN-38	0.0891
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T258M (No)	GDSC	SN-38	0.004
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T258M (No)	GDSC	SN-38	0.0018
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T258M (No)	GDSC	Camptothecin	0.0105
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T258M (No)	GDSC	Irinotecan	1.8877
SIDM00781	COREAD\|large_intestine	p.I714T (No)	GDSC	SN-38	0.0892
SIDM00781	COREAD\|large_intestine	p.I714T (No)	GDSC	SN-38	0.02
SIDM00781	COREAD\|large_intestine	p.I714T (No)	GDSC	Camptothecin	1.0697
SIDM00781	COREAD\|large_intestine	p.I714T (No)	GDSC	Irinotecan	149.51
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.Q704K (No)	GDSC	SN-38	0.0004
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.Q704K (No)	GDSC	SN-38	0.0476
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.Q704K (No)	GDSC	Camptothecin	0.4373
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.Q704K (No)	GDSC	Irinotecan	52.774
SIDM00675	BRCA\|breast	p.K326R (No)	GDSC	SN-38	0.0112
SIDM00675	BRCA\|breast	p.K326R (No)	GDSC	SN-38	0.009
SIDM00675	BRCA\|breast	p.K326R (No)	GDSC	Camptothecin	0.1251
SIDM00675	BRCA\|breast	p.K326R (No)	GDSC	Irinotecan	28.854
SIDM00946	ALL\|T_cell_leukemia	p.M428T (No)	GDSC	SN-38	0.0019
SIDM00946	ALL\|T_cell_leukemia	p.M428T (No)	GDSC	SN-38	0.003
SIDM00946	ALL\|T_cell_leukemia	p.M428T (No)	GDSC	Camptothecin	0.0099
SIDM00946	ALL\|T_cell_leukemia	p.M428T (No)	GDSC	Irinotecan	1.0055
SIDM00568	STAD\|stomach	p.E710D (No)	GDSC	SN-38	0.0248
SIDM00568	STAD\|stomach	p.E710D (No)	GDSC	SN-38	0.0108
SIDM00568	STAD\|stomach	p.E710D (No)	GDSC	Camptothecin	0.0608
SIDM00568	STAD\|stomach	p.E710D (No)	GDSC	Irinotecan	4.8487
SIDM00999	BLCA\|bladder	p.G109V (No)	GDSC	SN-38	0.0015
SIDM00999	BLCA\|bladder	p.G109V (No)	GDSC	SN-38	0.001
SIDM00999	BLCA\|bladder	p.G109V (No)	GDSC	Camptothecin	0.0059
SIDM00999	BLCA\|bladder	p.G109V (No)	GDSC	Irinotecan	1.0405
SIDM00590	HNSC\|head_and_neck	p.H81R (No)	GDSC	SN-38	0.0035
SIDM00590	HNSC\|head_and_neck	p.H81R (No)	GDSC	SN-38	0.0047
SIDM00590	HNSC\|head_and_neck	p.H81R (No)	GDSC	Camptothecin	0.012
SIDM00590	HNSC\|head_and_neck	p.H81R (No)	GDSC	Irinotecan	2.1974
SIDM00217	COREAD\|large_intestine	p.R405W (Yes)	GDSC	SN-38	0.008
SIDM00217	COREAD\|large_intestine	p.R405W (Yes)	GDSC	SN-38	1.1601
SIDM00217	COREAD\|large_intestine	p.R405W (Yes)	GDSC	Camptothecin	2.1264
SIDM00217	COREAD\|large_intestine	p.R405W (Yes)	GDSC	Irinotecan	182.69
SIDM00217	COREAD\|large_intestine	p.Y426C (No)	GDSC	SN-38	0.008
SIDM00217	COREAD\|large_intestine	p.Y426C (No)	GDSC	SN-38	1.1601
SIDM00217	COREAD\|large_intestine	p.Y426C (No)	GDSC	Camptothecin	2.1264
SIDM00217	COREAD\|large_intestine	p.Y426C (No)	GDSC	Irinotecan	182.69
SIDM00217	COREAD\|large_intestine	p.R434Q (No)	GDSC	SN-38	0.008
SIDM00217	COREAD\|large_intestine	p.R434Q (No)	GDSC	SN-38	1.1601
SIDM00217	COREAD\|large_intestine	p.R434Q (No)	GDSC	Camptothecin	2.1264
SIDM00217	COREAD\|large_intestine	p.R434Q (No)	GDSC	Irinotecan	182.69
SIDM00217	COREAD\|large_intestine	p.E517K (No)	GDSC	SN-38	0.008
SIDM00217	COREAD\|large_intestine	p.E517K (No)	GDSC	SN-38	1.1601
SIDM00217	COREAD\|large_intestine	p.E517K (No)	GDSC	Camptothecin	2.1264
SIDM00217	COREAD\|large_intestine	p.E517K (No)	GDSC	Irinotecan	182.69
SIDM00282	COREAD\|large_intestine	p.F279L (No)	GDSC	SN-38	0.0755
SIDM00282	COREAD\|large_intestine	p.F279L (No)	GDSC	SN-38	0.0319
SIDM00282	COREAD\|large_intestine	p.F279L (No)	GDSC	Camptothecin	0.0803
SIDM00282	COREAD\|large_intestine	p.F279L (No)	GDSC	Irinotecan	15.104
SIDM00954	BRCA\|breast	p.S111P (No)	GDSC	SN-38	0.2052
SIDM00954	BRCA\|breast	p.S111P (No)	GDSC	SN-38	0.2114
SIDM00954	BRCA\|breast	p.S111P (No)	GDSC	Camptothecin	0.9572
SIDM00954	BRCA\|breast	p.S111P (No)	GDSC	Irinotecan	127.88
SIDM00789	COREAD\|large_intestine	p.M675I (No)	GDSC	SN-38	0.0398
SIDM00789	COREAD\|large_intestine	p.M675I (No)	GDSC	SN-38	0.0286
SIDM00789	COREAD\|large_intestine	p.M675I (No)	GDSC	Camptothecin	0.0567
SIDM00789	COREAD\|large_intestine	p.M675I (No)	GDSC	Irinotecan	13.563
SIDM00789	COREAD\|large_intestine	p.D760G (No)	GDSC	SN-38	0.0398
SIDM00789	COREAD\|large_intestine	p.D760G (No)	GDSC	SN-38	0.0286
SIDM00789	COREAD\|large_intestine	p.D760G (No)	GDSC	Camptothecin	0.0567
SIDM00789	COREAD\|large_intestine	p.D760G (No)	GDSC	Irinotecan	13.563
SIDM00534	COREAD\|large_intestine	p.D156Y (No)	GDSC	SN-38	0.0211
SIDM00534	COREAD\|large_intestine	p.D156Y (No)	GDSC	SN-38	0.0945
SIDM00534	COREAD\|large_intestine	p.D156Y (No)	GDSC	Camptothecin	0.2015
SIDM00534	COREAD\|large_intestine	p.D156Y (No)	GDSC	Irinotecan	101.22
SIDM00217	COREAD\|large_intestine	p.P176fs*4 (No)	GDSC	SN-38	0.008
SIDM00217	COREAD\|large_intestine	p.P176fs*4 (No)	GDSC	SN-38	1.1601
SIDM00217	COREAD\|large_intestine	p.P176fs*4 (No)	GDSC	Camptothecin	2.1264
SIDM00217	COREAD\|large_intestine	p.P176fs*4 (No)	GDSC	Irinotecan	182.69
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.E208K (No)	GDSC	SN-38	0.8025
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.E208K (No)	GDSC	SN-38	1.4581
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.E208K (No)	GDSC	Camptothecin	1.6329
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.E208K (No)	GDSC	Irinotecan	147.22
SIDM00541	COREAD\|large_intestine	p.D182A (No)	GDSC	SN-38	0.154
SIDM00541	COREAD\|large_intestine	p.D182A (No)	GDSC	SN-38	0.1784
SIDM00541	COREAD\|large_intestine	p.D182A (No)	GDSC	Camptothecin	0.6875
SIDM00541	COREAD\|large_intestine	p.D182A (No)	GDSC	Irinotecan	78.252
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P235T (No)	GDSC	SN-38	0.016
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P235T (No)	GDSC	SN-38	0.0279
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P235T (No)	GDSC	Camptothecin	0.0709
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.P235T (No)	GDSC	Irinotecan	13.058
SIDM00837	COREAD\|large_intestine	p.W754C (No)	GDSC	SN-38	0.0039
SIDM00837	COREAD\|large_intestine	p.W754C (No)	GDSC	SN-38	0.0037
SIDM00837	COREAD\|large_intestine	p.W754C (No)	GDSC	Camptothecin	0.0227
SIDM00837	COREAD\|large_intestine	p.W754C (No)	GDSC	Irinotecan	2.8556
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.K175N (No)	GDSC	SN-38	0.0002
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.K175N (No)	GDSC	SN-38	0.0317
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.K184E (No)	GDSC	SN-38	0.0001
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.K184E (No)	GDSC	Camptothecin	0.0307
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.K184E (No)	GDSC	Irinotecan	2.9261
SIDM00193	COREAD\|large_intestine	p.K59N (No)	GDSC	SN-38	0.0805
SIDM00193	COREAD\|large_intestine	p.K59N (No)	GDSC	SN-38	0.0245
SIDM00193	COREAD\|large_intestine	p.K59N (No)	GDSC	Camptothecin	0.7161
SIDM00193	COREAD\|large_intestine	p.K59N (No)	GDSC	Irinotecan	73.12
SIDM00193	COREAD\|large_intestine	p.R89Q (No)	GDSC	SN-38	0.0805
SIDM00193	COREAD\|large_intestine	p.R89Q (No)	GDSC	SN-38	0.0245
SIDM00193	COREAD\|large_intestine	p.R89Q (No)	GDSC	Camptothecin	0.7161
SIDM00193	COREAD\|large_intestine	p.R89Q (No)	GDSC	Irinotecan	73.12
SIDM00193	COREAD\|large_intestine	p.K150N (No)	GDSC	SN-38	0.0805
SIDM00193	COREAD\|large_intestine	p.K150N (No)	GDSC	SN-38	0.0245
SIDM00193	COREAD\|large_intestine	p.K150N (No)	GDSC	Camptothecin	0.7161
SIDM00193	COREAD\|large_intestine	p.K150N (No)	GDSC	Irinotecan	73.12
SIDM00852	LGG\|glioma	p.A351D (No)	GDSC	SN-38	0.0028
SIDM00852	LGG\|glioma	p.A351D (No)	GDSC	SN-38	0.0012
SIDM00852	LGG\|glioma	p.A351D (No)	GDSC	Camptothecin	0.0078
SIDM00852	LGG\|glioma	p.A351D (No)	GDSC	Irinotecan	2.7333

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKDAKVPSP

Degron related mutations and impact score

Drug responses associated with TOP1 mutations

All proteins holding degron of SKDAKVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11387	DNA topoisomerase 1	DEG_COP1_1	387:395	SKDAKVPSP	COP1	0.9888	More...