DegronMD - P11678(EPX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M422I	TCGA-22-4613	LUSC	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.0833
p.M422I	DO26468	LUSC	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.0833
p.A444T	TCGA-BR-6452	STAD	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1944
p.A444T	DO38404	STAD	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1944
p.D433Y	TCGA-BS-A0UF	UCEC	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation altering degron motif	0.6214
p.D433Y	DO41488	UCEC	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation altering degron motif	0.6214
p.G449W	TCGA-D3-A3CB	SKCM	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.0556
p.G449W	DO47386	SKCM	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.0556
p.R432Q	TCGA-D3-A8GM	SKCM	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation altering degron motif	0.7329
p.R432Q	DO50288	SKCM	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation altering degron motif	0.7329
p.R445S	TCGA-E2-A1LH	BRCA	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1667
p.D433N	TCGA-FI-A2D0	UCEC	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation altering degron motif	0.5821
p.D433N	DO43891	UCEC	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation altering degron motif	0.5821
p.R443Q	TCGA-FW-A3R5	SKCM	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.2222
p.R443Q	DO37406	SKCM	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.2222
p.R446T	TCGA-Q1-A73O	CESC	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1389
p.R446T	DO51612	CESC	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1389
p.V426I	TCGA-VQ-A8P2	STAD	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1944
p.V426I	DO229177	LMS	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1944
p.V426I	DO51761	STAD	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1944
p.K441N	DO229026	LICA	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.2778
p.K441T	DO52365	LUSC	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.2778
p.R445K	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1667
p.R445K	ACH-000855	Esophageal Cancer	CCLE	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1667
p.R445K	ACH-002023	Colon/Colorectal Cancer	CCLE	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1667
p.R445K	KYSE-150	oesophagus	COSMIC	YRDFLPLVL	DEG_APCC_DBOX_1	431:439	Mutation rewiring degron network	0.1667

Kaplan plot for EPX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPX

UniProt ID: P11678

Entrez ID: 8288

Protein name: Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPX in