DegronMD

Uniprot ID: P11678

Source protein: Eosinophil peroxidase

Source gene: EPX

Class: DEG_APCC_DBOX_1

Location: 431:439

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5744

ASA_SCORE: 36.4444

COIL: 0.2251

CONS_SCORE: 0.7022

DSS_SCORE: 0.0403

HELIX: 0.7618

FCONS_SCORE: 1.2259

RIG_SCORE: 0.9556

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M422I	TCGA-22-4613	LUSC	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	0.0833
p.M422I	DO26468	LUSC	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.0833
p.A444T	TCGA-BR-6452	STAD	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	0.1944
p.A444T	DO38404	STAD	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.1944
p.D433Y	TCGA-BS-A0UF	UCEC	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	0.6214
p.D433Y	DO41488	UCEC	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.6214
p.G449W	TCGA-D3-A3CB	SKCM	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	0.0556
p.G449W	DO47386	SKCM	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.0556
p.R432Q	TCGA-D3-A8GM	SKCM	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	0.7329
p.R432Q	DO50288	SKCM	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.7329
p.R445S	TCGA-E2-A1LH	BRCA	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	0.1667
p.D433N	TCGA-FI-A2D0	UCEC	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	0.5821
p.D433N	DO43891	UCEC	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.5821
p.R443Q	TCGA-FW-A3R5	SKCM	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	0.2222
p.R443Q	DO37406	SKCM	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.2222
p.R446T	TCGA-Q1-A73O	CESC	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	0.1389
p.R446T	DO51612	CESC	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.1389
p.V426I	TCGA-VQ-A8P2	STAD	TCGA	YRDFLPLVL	DEG_APCC_DBOX_1	0.1944
p.V426I	DO229177	LMS	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.1944
p.V426I	DO51761	STAD	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.1944
p.K441N	DO229026	LICA	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.2778
p.K441T	DO52365	LUSC	ICGC	YRDFLPLVL	DEG_APCC_DBOX_1	0.2778
p.R445K	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	YRDFLPLVL	DEG_APCC_DBOX_1	0.1667
p.R445K	ACH-000855	Esophageal Cancer	CCLE	YRDFLPLVL	DEG_APCC_DBOX_1	0.1667
p.R445K	ACH-002023	Colon/Colorectal Cancer	CCLE	YRDFLPLVL	DEG_APCC_DBOX_1	0.1667
p.R445K	KYSE-150	oesophagus	COSMIC	YRDFLPLVL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11678	Eosinophil peroxidase	DEG_APCC_DBOX_1	431:439	YRDFLPLVL	APC,CDC20,FZR1	0.5744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: YRDFLPLVL

Degron related mutations and impact score

Drug responses associated with EPX mutations

All proteins holding degron of YRDFLPLVL