DegronMD - P12272(PTHLH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G159R	TCGA-17-Z042	LUAD	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.2222
p.R141Q	TCGA-3A-A9I7	PAAD	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1111
p.R141Q	DO51678	PAAD	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1111
p.R144L	TCGA-55-7910	LUAD	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1944
p.R144L	DO23669	LUAD	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1944
p.K139E	TCGA-EE-A29L	SKCM	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation substituting flanking lysine	0.1667
p.K139E	DO222599	MELA	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation substituting flanking lysine	0.1667
p.K139E	DO37835	SKCM	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation substituting flanking lysine	0.1667
p.K140T	TCGA-EO-A22X	UCEC	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation substituting flanking lysine	0.1944
p.K140T	DO43907	UCEC	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation substituting flanking lysine	0.1944
p.E158A	TCGA-F5-6814	READ	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.25
p.E158A	DO36556	READ	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.25
p.G159V	TCGA-FS-A1ZJ	SKCM	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.2222
p.G159V	DO37956	SKCM	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.2222
p.R144C	TCGA-FW-A3R5	SKCM	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1944
p.R144C	TCGA-ZJ-AAXT	CESC	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1944
p.R144C	DO219758	CESC	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1944
p.R144C	DO37406	SKCM	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1944
p.R144C	SIDM01588	Endometrial Carcinoma	GDSC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1944
p.R144C	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1944
p.L162P	TCGA-G4-6314	COAD	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1389
p.L162P	DO10381	COAD	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1389
p.R142Q	TCGA-KB-A6F5	STAD	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1389
p.R142Q	DO50128	STAD	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1389
p.G154W	DO233823	GACA	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation altering degron motif	0.6714
p.D160E	DO229037	LICA	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.1944
p.S145T	DO227931	PBCA	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation rewiring degron network	0.2222
p.D149E	SIDM00338	Acute Myeloid Leukemia	GDSC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation altering degron motif	0.6758
p.D149E	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation altering degron motif	0.6758
p.D149E	SIDM00192	Colorectal Carcinoma	GDSC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation altering degron motif	0.6758
p.D149E	SIDM01442	Glioma	GDSC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation altering degron motif	0.6758
p.D149E	ME-1	haematopoietic and lymphoid tissue	COSMIC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation altering degron motif	0.6758
p.D149E	EBC-1	lung	COSMIC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation altering degron motif	0.6758
p.D149G	ACH-002240	Lymphoma	CCLE	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation altering degron motif	0.7198
p.D149G	H9	haematopoietic and lymphoid tissue	COSMIC	DSGVTGS	DEG_SCF_TRCP1_1	149:155	Mutation altering degron motif	0.7198

Kaplan plot for PTHLH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTHLH

UniProt ID: P12272

Entrez ID: 5744

Protein name: Parathyroid hormone-related protein (PTH-rP) (PTHrP) (Parathyroid hormone-like protein) (PLP) [Cleaved into: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTHLH in