DegronMD

Uniprot ID: P12272

Source protein: Parathyroid hormone-related protein

Source gene: PTHLH

Class: DEG_SCF_TRCP1_1

Location: 149:155

E3 ligase: BTRC

DEGRON score: 0.9677

ASA_SCORE: 59.5714

COIL: 0.7639

CONS_SCORE: 0.4884

DSS_SCORE: 0.5734

HELIX: 0.0674

FCONS_SCORE: 0.7836

RIG_SCORE: 0.6377

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G159R	TCGA-17-Z042	LUAD	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	0.2222
p.R141Q	TCGA-3A-A9I7	PAAD	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	0.1111
p.R141Q	DO51678	PAAD	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.1111
p.R144L	TCGA-55-7910	LUAD	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	0.1944
p.R144L	DO23669	LUAD	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.1944
p.K139E	TCGA-EE-A29L	SKCM	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	0.1667
p.K139E	DO222599	MELA	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.1667
p.K139E	DO37835	SKCM	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.1667
p.K140T	TCGA-EO-A22X	UCEC	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	0.1944
p.K140T	DO43907	UCEC	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.1944
p.E158A	TCGA-F5-6814	READ	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	0.25
p.E158A	DO36556	READ	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.25
p.G159V	TCGA-FS-A1ZJ	SKCM	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	0.2222
p.G159V	DO37956	SKCM	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.2222
p.R144C	TCGA-FW-A3R5	SKCM	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	0.1944
p.R144C	TCGA-ZJ-AAXT	CESC	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	0.1944
p.R144C	DO219758	CESC	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.1944
p.R144C	DO37406	SKCM	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.1944
p.R144C	SIDM01588	Endometrial Carcinoma	GDSC	DSGVTGS	DEG_SCF_TRCP1_1	0.1944
p.R144C	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGVTGS	DEG_SCF_TRCP1_1	0.1944
p.L162P	TCGA-G4-6314	COAD	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	0.1389
p.L162P	DO10381	COAD	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.1389
p.R142Q	TCGA-KB-A6F5	STAD	TCGA	DSGVTGS	DEG_SCF_TRCP1_1	0.1389
p.R142Q	DO50128	STAD	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.1389
p.G154W	DO233823	GACA	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.6714
p.D160E	DO229037	LICA	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.1944
p.S145T	DO227931	PBCA	ICGC	DSGVTGS	DEG_SCF_TRCP1_1	0.2222
p.D149E	SIDM00338	Acute Myeloid Leukemia	GDSC	DSGVTGS	DEG_SCF_TRCP1_1	0.6758
p.D149E	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	DSGVTGS	DEG_SCF_TRCP1_1	0.6758
p.D149E	SIDM00192	Colorectal Carcinoma	GDSC	DSGVTGS	DEG_SCF_TRCP1_1	0.6758
p.D149E	SIDM01442	Glioma	GDSC	DSGVTGS	DEG_SCF_TRCP1_1	0.6758
p.D149E	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVTGS	DEG_SCF_TRCP1_1	0.6758
p.D149E	EBC-1	lung	COSMIC	DSGVTGS	DEG_SCF_TRCP1_1	0.6758
p.D149G	ACH-002240	Lymphoma	CCLE	DSGVTGS	DEG_SCF_TRCP1_1	0.7198
p.D149G	H9	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVTGS	DEG_SCF_TRCP1_1	0.7198

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGVTGS

Degron related mutations and impact score

Drug responses associated with PTHLH mutations

All proteins holding degron of DSGVTGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12272	Parathyroid hormone-related protein	DEG_SCF_TRCP1_1	149:155	DSGVTGS	BTRC	0.9677	More...