DegronMD - P12643(BMP2)

GO - Biological processes (BP): animal organ morphogenesis [GO:0009887]; aortic valve development [GO:0003176]; atrioventricular canal morphogenesis [GO:1905222]; atrioventricular valve morphogenesis [GO:0003181]; BMP signaling pathway [GO:0030509]; BMP signaling pathway involved in heart development [GO:0061312]; BMP signaling pathway involved in heart induction [GO:0003130]; bone mineralization [GO:0030282]; bone mineralization involved in bone maturation [GO:0035630]; branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac atrium formation [GO:0003210]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac jelly development [GO:1905072]; cardiac muscle cell differentiation [GO:0055007]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiocyte differentiation [GO:0035051]; cell-cell signaling [GO:0007267]; cell fate commitment [GO:0045165]; cellular response to BMP stimulus [GO:0071773]; cellular response to organic cyclic compound [GO:0071407]; chondrocyte differentiation [GO:0002062]; corticotropin hormone secreting cell differentiation [GO:0060128]; embryonic heart tube anterior/posterior pattern specification [GO:0035054]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; epithelial to mesenchymal transition [GO:0001837]; gene expression [GO:0010467]; heart development [GO:0007507]; inflammatory response [GO:0006954]; inner ear development [GO:0048839]; in utero embryonic development [GO:0001701]; mesenchymal cell differentiation [GO:0048762]; mesenchymal cell proliferation involved in ureteric bud development [GO:0072138]; mesenchyme development [GO:0060485]; negative regulation of aldosterone biosynthetic process [GO:0032348]; negative regulation of calcium-independent cell-cell adhesion [GO:0051042]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell differentiation [GO:2000726]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cortisol biosynthetic process [GO:2000065]; negative regulation of gene expression [GO:0010629]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of Wnt signaling pathway involved in heart development [GO:0003308]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; pericardium development [GO:0060039]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of odontogenesis [GO:0042482]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]; positive regulation of phosphatase activity [GO:0010922]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway by BMP signaling pathway [GO:0060804]; protein destabilization [GO:0031648]; protein phosphorylation [GO:0006468]; proteoglycan metabolic process [GO:0006029]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of transcription, DNA-templated [GO:0006355]; response to bacterium [GO:0009617]; response to hypoxia [GO:0001666]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]; telencephalon development [GO:0021537]; telencephalon regionalization [GO:0021978]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R291C	TCGA-AN-A03X	BRCA	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.1389
p.R291C	DO2885	BRCA	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.1389
p.R289Q	TCGA-AP-A1DO	UCEC	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.0833
p.R289Q	TCGA-FR-A726	SKCM	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.0833
p.R289Q	DO48665	SKCM	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.0833
p.R289Q	DO43250	UCEC	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.0833
p.R298I	TCGA-AP-A1DV	UCEC	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.8102
p.R298I	DO43186	UCEC	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.8102
p.V308M	TCGA-CR-7370	HNSC	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.2222
p.V308M	DO14426	HNSC	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.2222
p.K297N	TCGA-D8-A1JG	BRCA	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.3056
p.K297N	DO1256	BRCA	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.3056
p.K293T	TCGA-FS-A1ZN	SKCM	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation substituting flanking lysine	0.3056
p.K293T	DO38165	SKCM	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation substituting flanking lysine	0.3056
p.D304E	DO225166	BRCA	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.5647
p.V303M	DO49080	PACA	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6097
p.V303M	SIDM01649	Non-Cancerous	GDSC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6097
p.V303M	SIDM00184	Melanoma	GDSC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6097
p.V303M	ACH-002355	Non-Cancerous	CCLE	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation altering degron motif	0.6097
p.W310L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.1667
p.W310L	ACH-000845	Lung Cancer	CCLE	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.1667
p.W310C	ACH-001172	Brain Cancer	CCLE	RHPLYVD	LIG_APCC_ABBAyCdc20_2	298:304	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BMP2

UniProt ID: P12643

Entrez ID: 650

Protein name: Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BMP2 in