DegronMD

Uniprot ID: P12643

Source protein: Bone morphogenetic protein 2

Source gene: BMP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 298:304

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7287

ASA_SCORE: 69.5

COIL: 0.3286

CONS_SCORE: 0.7791

DSS_SCORE: 0.2099

HELIX: 0.0596

FCONS_SCORE: 1.239

RIG_SCORE: 0.8058

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R291C	TCGA-AN-A03X	BRCA	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R291C	DO2885	BRCA	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R289Q	TCGA-AP-A1DO	UCEC	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R289Q	TCGA-FR-A726	SKCM	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R289Q	DO48665	SKCM	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R289Q	DO43250	UCEC	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R298I	TCGA-AP-A1DV	UCEC	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.8102
p.R298I	DO43186	UCEC	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.8102
p.V308M	TCGA-CR-7370	HNSC	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V308M	DO14426	HNSC	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.K297N	TCGA-D8-A1JG	BRCA	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.K297N	DO1256	BRCA	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.K293T	TCGA-FS-A1ZN	SKCM	TCGA	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.K293T	DO38165	SKCM	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D304E	DO225166	BRCA	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.5647
p.V303M	DO49080	PACA	ICGC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V303M	SIDM01649	Non-Cancerous	GDSC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V303M	SIDM00184	Melanoma	GDSC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V303M	ACH-002355	Non-Cancerous	CCLE	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.6097
p.W310L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.W310L	ACH-000845	Lung Cancer	CCLE	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.W310C	ACH-001172	Brain Cancer	CCLE	RHPLYVD	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12643	Bone morphogenetic protein 2	LIG_APCC_ABBAyCdc20_2	298:304	RHPLYVD	APC,CDC20,FZR1	0.7287	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons