DegronMD - P12830(CDH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A408P	TCGA-55-A4DF	LUAD	TCGA	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.6392
p.A408P	DO45318	LUAD	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.6392
p.A403T	TCGA-A5-A0GA	UCEC	TCGA	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.3056
p.A403T	DO43763	UCEC	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.3056
p.D400V	TCGA-CD-5799	STAD	TCGA	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2222
p.D400V	DO233758	GACA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2222
p.D400V	DO38775	STAD	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2222
p.D402H	TCGA-D7-8572	STAD	TCGA	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2778
p.D402H	TCGA-E9-A2JT	BRCA	TCGA	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2778
p.D402H	DO3964	BRCA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2778
p.D402H	DO233615	GACA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2778
p.D402H	DO47735	STAD	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2778
p.D402H	SIDM02040	Esophageal Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2778
p.W409L	TCGA-GI-A2C8	BRCA	TCGA	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.5904
p.W409L	DO5992	BRCA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.5904
p.D400N	DO224732	BRCA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2222
p.N397K	DO233671	GACA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation substituting flanking lysine	0.25
p.T414A	DO233885	GACA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2222
p.V399L	DO26052	LUAD	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.1944
p.D400G	DO35442	PACA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2222
p.S404F	DO232224	PBCA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.7982
p.V414M	DO36397	READ	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2222
p.P400S	DO47282	SKCM	ICGC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2222
p.D402N	SIDM00938	Breast Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2778
p.D402N	ACH-000902	Breast Cancer	CCLE	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2778
p.D402N	CAL-148	breast	COSMIC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2778
p.E410K	SIDM00419	Ewing's Sarcoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.7022
p.E410K	TC-71	bone	COSMIC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.7022
p.I415T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.1944
p.I415T	H513	pleura	COSMIC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.1944
p.N405S	SIDM01083	Oral Cavity Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.5958
p.N405S	ACH-000254	Head and Neck Cancer	CCLE	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.5958
p.N405S	SCC-15	upper aerodigestive tract	COSMIC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.5958
p.T406A	SIDM01608	Endometrial Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.7139
p.T406A	ACH-000990	Endometrial/Uterine Cancer	CCLE	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation altering degron motif	0.7139
p.D400A	SIDM00780	Colorectal Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2222
p.D400A	ACH-000967	Colon/Colorectal Cancer	CCLE	PNTPAWE	DEG_SCF_FBW7_2	404:410	Mutation rewiring degron network	0.2222

Kaplan plot for CDH1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH1

UniProt ID: P12830

Entrez ID: 999

Protein name: Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH1 in