DegronMD

Uniprot ID: P12830

Source protein: Cadherin-1

Source gene: CDH1

Class: DEG_SCF_FBW7_2

Location: 404:410

E3 ligase: FBXW7

DEGRON score: 0.9053

ASA_SCORE: 62.3143

COIL: 0.7346

CONS_SCORE: 0.4098

DSS_SCORE: 0.3137

HELIX: 0.0839

FCONS_SCORE: 0.709

RIG_SCORE: 0.8115

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A408P	TCGA-55-A4DF	LUAD	TCGA	PNTPAWE	DEG_SCF_FBW7_2	0.6392
p.A408P	DO45318	LUAD	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.6392
p.A403T	TCGA-A5-A0GA	UCEC	TCGA	PNTPAWE	DEG_SCF_FBW7_2	0.3056
p.A403T	DO43763	UCEC	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.3056
p.D400V	TCGA-CD-5799	STAD	TCGA	PNTPAWE	DEG_SCF_FBW7_2	0.2222
p.D400V	DO233758	GACA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.2222
p.D400V	DO38775	STAD	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.2222
p.D402H	TCGA-D7-8572	STAD	TCGA	PNTPAWE	DEG_SCF_FBW7_2	0.2778
p.D402H	TCGA-E9-A2JT	BRCA	TCGA	PNTPAWE	DEG_SCF_FBW7_2	0.2778
p.D402H	DO3964	BRCA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.2778
p.D402H	DO233615	GACA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.2778
p.D402H	DO47735	STAD	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.2778
p.D402H	SIDM02040	Esophageal Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	0.2778
p.W409L	TCGA-GI-A2C8	BRCA	TCGA	PNTPAWE	DEG_SCF_FBW7_2	0.5904
p.W409L	DO5992	BRCA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.5904
p.D400N	DO224732	BRCA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.2222
p.N397K	DO233671	GACA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.25
p.T414A	DO233885	GACA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.2222
p.V399L	DO26052	LUAD	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.1944
p.D400G	DO35442	PACA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.2222
p.S404F	DO232224	PBCA	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.7982
p.V414M	DO36397	READ	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.2222
p.P400S	DO47282	SKCM	ICGC	PNTPAWE	DEG_SCF_FBW7_2	0.2222
p.D402N	SIDM00938	Breast Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	0.2778
p.D402N	ACH-000902	Breast Cancer	CCLE	PNTPAWE	DEG_SCF_FBW7_2	0.2778
p.D402N	CAL-148	breast	COSMIC	PNTPAWE	DEG_SCF_FBW7_2	0.2778
p.E410K	SIDM00419	Ewing's Sarcoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	0.7022
p.E410K	TC-71	bone	COSMIC	PNTPAWE	DEG_SCF_FBW7_2	0.7022
p.I415T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	0.1944
p.I415T	H513	pleura	COSMIC	PNTPAWE	DEG_SCF_FBW7_2	0.1944
p.N405S	SIDM01083	Oral Cavity Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	0.5958
p.N405S	ACH-000254	Head and Neck Cancer	CCLE	PNTPAWE	DEG_SCF_FBW7_2	0.5958
p.N405S	SCC-15	upper_aerodigestive_tract	COSMIC	PNTPAWE	DEG_SCF_FBW7_2	0.5958
p.T406A	SIDM01608	Endometrial Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	0.7139
p.T406A	ACH-000990	Endometrial/Uterine Cancer	CCLE	PNTPAWE	DEG_SCF_FBW7_2	0.7139
p.D400A	SIDM00780	Colorectal Carcinoma	GDSC	PNTPAWE	DEG_SCF_FBW7_2	0.2222
p.D400A	ACH-000967	Colon/Colorectal Cancer	CCLE	PNTPAWE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNTPAWE

Degron related mutations and impact score

Drug responses associated with CDH1 mutations

All proteins holding degron of PNTPAWE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12830	Cadherin-1	DEG_SCF_FBW7_2	404:410	PNTPAWE	FBXW7	0.9053	More...