DegronMD - P13349(MYF5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T236N	TCGA-05-4424	LUAD	TCGA	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.2222
p.T236N	TCGA-L9-A7SV	LUAD	TCGA	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.2222
p.T236N	DO49875	LUAD	ICGC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.2222
p.T236N	DO23672	LUAD	ICGC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.2222
p.G244A	TCGA-CC-A9FU	LIHC	TCGA	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation altering degron motif	0.6429
p.G244A	DO52190	LIHC	ICGC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation altering degron motif	0.6429
p.A245V	TCGA-E7-A97Q	BLCA	TCGA	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation altering degron motif	0.5825
p.A245V	DO219022	BLCA	ICGC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation altering degron motif	0.5825
p.T236I	TCGA-EB-A5UM	SKCM	TCGA	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.2222
p.T236I	DO47282	SKCM	ICGC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.2222
p.H253Y	TCGA-EE-A29E	SKCM	TCGA	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.1389
p.H253Y	DO37831	SKCM	ICGC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.1389
p.P232L	TCGA-K4-A5RH	BLCA	TCGA	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.1111
p.P232L	DO219028	BLCA	ICGC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.1111
p.V254M	TCGA-NJ-A4YQ	LUAD	TCGA	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.1111
p.V254M	DO218944	LUAD	ICGC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.1111
p.R249S	DO234314	ESAD	ICGC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.25
p.H253R	DO50797	LICA	ICGC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.1389
p.S235I	DO231902	LINC	ICGC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.1944
p.D237N	SIDM01175	Other Sarcomas	GDSC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.25
p.D237N	SIDM00286	Neuroblastoma	GDSC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.25
p.D237N	SIDM01561	Melanoma	GDSC	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.25
p.D237N	ACH-000136	Neuroblastoma	CCLE	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.25
p.D237N	ACH-000799	Skin Cancer	CCLE	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.25
p.D237N	ACH-002309	Sarcoma	CCLE	PATPGAS	DEG_SCF_FBW7_1	240:246	Mutation rewiring degron network	0.25

Kaplan plot for MYF5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYF5

UniProt ID: P13349

Entrez ID: 4617

Protein name: Myogenic factor 5 (Myf-5) (Class C basic helix-loop-helix protein 2) (bHLHc2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYF5 in