DegronMD

Uniprot ID: P13349

Source protein: Myogenic factor 5

Source gene: MYF5

Class: DEG_SCF_FBW7_1

Location: 240:246

E3 ligase: FBXW7

DEGRON score: 0.8809

ASA_SCORE: 73.4857

COIL: 0.9364

CONS_SCORE: 0.4859

DSS_SCORE: 0.5288

HELIX: 0.0369

FCONS_SCORE: 1.0723

RIG_SCORE: 0.5995

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T236N	TCGA-05-4424	LUAD	TCGA	PATPGAS	DEG_SCF_FBW7_1	0.2222
p.T236N	TCGA-L9-A7SV	LUAD	TCGA	PATPGAS	DEG_SCF_FBW7_1	0.2222
p.T236N	DO49875	LUAD	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.2222
p.T236N	DO23672	LUAD	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.2222
p.G244A	TCGA-CC-A9FU	LIHC	TCGA	PATPGAS	DEG_SCF_FBW7_1	0.6429
p.G244A	DO52190	LIHC	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.6429
p.A245V	TCGA-E7-A97Q	BLCA	TCGA	PATPGAS	DEG_SCF_FBW7_1	0.5825
p.A245V	DO219022	BLCA	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.5825
p.T236I	TCGA-EB-A5UM	SKCM	TCGA	PATPGAS	DEG_SCF_FBW7_1	0.2222
p.T236I	DO47282	SKCM	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.2222
p.H253Y	TCGA-EE-A29E	SKCM	TCGA	PATPGAS	DEG_SCF_FBW7_1	0.1389
p.H253Y	DO37831	SKCM	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.1389
p.P232L	TCGA-K4-A5RH	BLCA	TCGA	PATPGAS	DEG_SCF_FBW7_1	0.1111
p.P232L	DO219028	BLCA	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.1111
p.V254M	TCGA-NJ-A4YQ	LUAD	TCGA	PATPGAS	DEG_SCF_FBW7_1	0.1111
p.V254M	DO218944	LUAD	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.1111
p.R249S	DO234314	ESAD	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.25
p.H253R	DO50797	LICA	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.1389
p.S235I	DO231902	LINC	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.1944
p.D237N	SIDM01175	Other Sarcomas	GDSC	PATPGAS	DEG_SCF_FBW7_1	0.25
p.D237N	SIDM00286	Neuroblastoma	GDSC	PATPGAS	DEG_SCF_FBW7_1	0.25
p.D237N	SIDM01561	Melanoma	GDSC	PATPGAS	DEG_SCF_FBW7_1	0.25
p.D237N	ACH-000136	Neuroblastoma	CCLE	PATPGAS	DEG_SCF_FBW7_1	0.25
p.D237N	ACH-000799	Skin Cancer	CCLE	PATPGAS	DEG_SCF_FBW7_1	0.25
p.D237N	ACH-002309	Sarcoma	CCLE	PATPGAS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons