DegronMD

Uniprot ID: Q9H3U1

Source protein: Protein unc-45 homolog A

Source gene: UNC45A

Class: DEG_SCF_FBW7_1

Location: 13:19

E3 ligase: FBXW7

DEGRON score: 0.872

ASA_SCORE: 78.2714

COIL: 0.8329

CONS_SCORE: 0.2379

DSS_SCORE: 0.7312

HELIX: 0.1424

FCONS_SCORE: 0.9218

RIG_SCORE: 0.6122

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E22D	TCGA-06-5416	GBM	TCGA	PATPGAS	DEG_SCF_FBW7_1	0.25
p.E22D	DO10880	GBM	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.25
p.P11H	TCGA-CM-6171	COAD	TCGA	PATPGAS	DEG_SCF_FBW7_1	0.2778
p.P11H	DO8151	COAD	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.2778
p.V21E	TCGA-CZ-5989	KIRC	TCGA	PATPGAS	DEG_SCF_FBW7_1	0.2778
p.V21E	DO18322	KIRC	ICGC	PATPGAS	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons