DegronMD - P13533(MYH6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H653N	TCGA-44-7662	LUAD	TCGA	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation altering degron motif	0.6312
p.H653N	DO23597	LUAD	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation altering degron motif	0.6312
p.H668R	TCGA-77-7337	LUSC	TCGA	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation rewiring degron network	0.1389
p.H668R	DO27445	LUSC	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation rewiring degron network	0.1389
p.K659M	TCGA-86-7955	LUAD	TCGA	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation altering degron motif	0.6951
p.K659M	DO23612	LUAD	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation altering degron motif	0.6951
p.S650L	TCGA-AN-A046	BRCA	TCGA	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation blocking phosphorylation signal	0.6944
p.S650L	DO1285	BRCA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation blocking phosphorylation signal	0.6944
p.L657I	TCGA-E6-A1LX	UCEC	TCGA	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation altering degron motif	0.7174
p.L657I	DO41020	UCEC	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation altering degron motif	0.7174
p.T648M	DO233041	GACA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation rewiring degron network	0.1944
p.T648M	DO230445	UTCA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation rewiring degron network	0.1944
p.P669H	DO232030	LICA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation rewiring degron network	0.1111
p.N658S	DO230530	LUSC	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation altering degron motif	0.5958
p.R665K	DO220872	MELA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation rewiring degron network	0.2222
p.L652F	DO222557	MELA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation rewiring degron network	0.3056
p.R654L	DO229245	THCA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation altering degron motif	0.8428
p.S645F	SIDM00007	Other Solid Cancers	GDSC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation rewiring degron network	0.1111
p.S645F	ACH-001550	Skin Cancer	CCLE	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation rewiring degron network	0.1111
p.S645F	MCC13	skin	COSMIC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation rewiring degron network	0.1111
p.R654P	SIDM00517	Head and Neck Carcinoma	GDSC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation altering degron motif	0.7512
p.R654P	H3118	upper aerodigestive tract	COSMIC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation altering degron motif	0.7512
p.T667A	SIDM01608	Endometrial Carcinoma	GDSC	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation blocking phosphorylation signal	0.6111
p.T667A	ACH-000990	Endometrial/Uterine Cancer	CCLE	HRENLNKLM	DEG_APCC_DBOX_1	653:661	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for MYH6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYH6

UniProt ID: P13533

Entrez ID: 4624

Protein name: Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYH6 in