DegronMD

Uniprot ID: P13533

Source protein: Myosin-6

Source gene: MYH6

Class: DEG_APCC_DBOX_1

Location: 653:661

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.857

ASA_SCORE: 60.0778

COIL: 0.0399

CONS_SCORE: 0.6354

DSS_SCORE: 0.4522

HELIX: 0.9561

FCONS_SCORE: 1.0898

RIG_SCORE: 0.7791

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H653N	TCGA-44-7662	LUAD	TCGA	HRENLNKLM	DEG_APCC_DBOX_1	0.6312
p.H653N	DO23597	LUAD	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.6312
p.H668R	TCGA-77-7337	LUSC	TCGA	HRENLNKLM	DEG_APCC_DBOX_1	0.1389
p.H668R	DO27445	LUSC	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.1389
p.K659M	TCGA-86-7955	LUAD	TCGA	HRENLNKLM	DEG_APCC_DBOX_1	0.6951
p.K659M	DO23612	LUAD	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.6951
p.S650L	TCGA-AN-A046	BRCA	TCGA	HRENLNKLM	DEG_APCC_DBOX_1	0.6944
p.S650L	DO1285	BRCA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.6944
p.L657I	TCGA-E6-A1LX	UCEC	TCGA	HRENLNKLM	DEG_APCC_DBOX_1	0.7174
p.L657I	DO41020	UCEC	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.7174
p.T648M	DO233041	GACA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.1944
p.T648M	DO230445	UTCA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.1944
p.P669H	DO232030	LICA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.1111
p.N658S	DO230530	LUSC	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.5958
p.R665K	DO220872	MELA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.2222
p.L652F	DO222557	MELA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.3056
p.R654L	DO229245	THCA	ICGC	HRENLNKLM	DEG_APCC_DBOX_1	0.8428
p.S645F	SIDM00007	Other Solid Cancers	GDSC	HRENLNKLM	DEG_APCC_DBOX_1	0.1111
p.S645F	ACH-001550	Skin Cancer	CCLE	HRENLNKLM	DEG_APCC_DBOX_1	0.1111
p.S645F	MCC13	skin	COSMIC	HRENLNKLM	DEG_APCC_DBOX_1	0.1111
p.R654P	SIDM00517	Head and Neck Carcinoma	GDSC	HRENLNKLM	DEG_APCC_DBOX_1	0.7512
p.R654P	H3118	upper_aerodigestive_tract	COSMIC	HRENLNKLM	DEG_APCC_DBOX_1	0.7512
p.T667A	SIDM01608	Endometrial Carcinoma	GDSC	HRENLNKLM	DEG_APCC_DBOX_1	0.6111
p.T667A	ACH-000990	Endometrial/Uterine Cancer	CCLE	HRENLNKLM	DEG_APCC_DBOX_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13533	Myosin-6	DEG_APCC_DBOX_1	653:661	HRENLNKLM	APC,CDC20,FZR1	0.857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons