DegronMD - P13861(PRKAR2A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E42K	TCGA-EA-A43B	CESC	TCGA	PAATPRQS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.0833
p.E42K	DO44384	CESC	ICGC	PAATPRQS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.0833
p.L59M	DO222794	COCA	ICGC	PAATPRQS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.3056
p.G60C	DO233864	GACA	ICGC	PAATPRQS	DEG_SCF_FBW7_1	51:58	Mutation rewiring degron network	0.2778
p.A53S	SIDM01265	Plasma Cell Myeloma	GDSC	PAATPRQS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.6477
p.A53S	SIDM00793	Burkitt's Lymphoma	GDSC	PAATPRQS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.6477
p.Q57H	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PAATPRQS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.647
p.Q57H	ACH-000893	Lung Cancer	CCLE	PAATPRQS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.647
p.A52T	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PAATPRQS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.6028
p.A52T	ACH-000851	Lung Cancer	CCLE	PAATPRQS	DEG_SCF_FBW7_1	51:58	Mutation altering degron motif	0.6028

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons