DegronMD

Uniprot ID: P13861

Source protein: cAMP-dependent protein kinase type II-alpha regulatory subunit

Source gene: PRKAR2A

Class: DEG_SCF_FBW7_1

Location: 51:58

E3 ligase: FBXW7

DEGRON score: 0.8823

ASA_SCORE: 88.2

COIL: 0.8973

CONS_SCORE: 0.4105

DSS_SCORE: 0.6925

HELIX: 0.0499

FCONS_SCORE: 0.9909

RIG_SCORE: 0.622

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E42K	TCGA-EA-A43B	CESC	TCGA	PAATPRQS	DEG_SCF_FBW7_1	0.0833
p.E42K	DO44384	CESC	ICGC	PAATPRQS	DEG_SCF_FBW7_1	0.0833
p.L59M	DO222794	COCA	ICGC	PAATPRQS	DEG_SCF_FBW7_1	0.3056
p.G60C	DO233864	GACA	ICGC	PAATPRQS	DEG_SCF_FBW7_1	0.2778
p.A53S	SIDM01265	Plasma Cell Myeloma	GDSC	PAATPRQS	DEG_SCF_FBW7_1	0.6477
p.A53S	SIDM00793	Burkitt's Lymphoma	GDSC	PAATPRQS	DEG_SCF_FBW7_1	0.6477
p.Q57H	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PAATPRQS	DEG_SCF_FBW7_1	0.647
p.Q57H	ACH-000893	Lung Cancer	CCLE	PAATPRQS	DEG_SCF_FBW7_1	0.647
p.A52T	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PAATPRQS	DEG_SCF_FBW7_1	0.6028
p.A52T	ACH-000851	Lung Cancer	CCLE	PAATPRQS	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13861	cAMP-dependent protein kinase type II-alpha regulatory subunit	DEG_SCF_FBW7_1	51:58	PAATPRQS	FBXW7	0.8823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons