DegronMD - P13995(MTHFD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M172L	TCGA-3X-AAVA	CHOL	TCGA	DQYSMLP	CBL_PTK	168:174	Mutation altering degron motif	0.5999
p.I184M	TCGA-92-7340	LUSC	TCGA	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.0556
p.R164Q	TCGA-AX-A0J0	UCEC	TCGA	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.2222
p.R164Q	TCGA-D1-A103	UCEC	TCGA	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.2222
p.I160S	TCGA-D1-A16X	UCEC	TCGA	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.1111
p.P177L	TCGA-EE-A2MR	SKCM	TCGA	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.25
p.V175M	DO51859	BLCA	ICGC	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.3056
p.R169M	DO223732	CESC	ICGC	DQYSMLP	CBL_PTK	168:174	Mutation altering degron motif	0.8632
p.I161V	DO222798	COCA	ICGC	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.1389
p.S178C	DO49051	HNSC	ICGC	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.2222
p.R173Q	DO14192	HNSC	ICGC	DQYSMLP	CBL_PTK	168:174	Mutation altering degron motif	0.7329
p.R173Q	DO229062	LICA	ICGC	DQYSMLP	CBL_PTK	168:174	Mutation altering degron motif	0.7329
p.E172D	DO229006	LICA	ICGC	DQYSMLP	CBL_PTK	168:174	Mutation altering degron motif	0.6758
p.L176M	DO43306	UCEC	ICGC	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.2778
p.K158N	DO41133	UCEC	ICGC	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.0556
p.V180M	SIDM01608	Endometrial Carcinoma	GDSC	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.1667
p.V180M	ACH-000990	Endometrial/Uterine Cancer	CCLE	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.1667
p.M165L	SIDM01611	Endometrial Carcinoma	GDSC	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.25
p.M165L	ACH-000996	Endometrial/Uterine Cancer	CCLE	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.25
p.Q169R	ACH-001441	Eye Cancer	CCLE	DQYSMLP	CBL_PTK	168:174	Mutation altering degron motif	0.6218
p.D166N	no-11	central nervous system	COSMIC	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.2778
p.V164I	PANC-08-13	pancreas	COSMIC	DQYSMLP	CBL_PTK	168:174	Mutation rewiring degron network	0.2222

Kaplan plot for MTHFD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTHFD2

UniProt ID: P13995

Entrez ID: 10797

Protein name: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTHFD2 in