DegronMD

Uniprot ID: P13995

Source protein: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

Source gene: MTHFD2

Class: CBL_PTK

Location: 168:174

E3 ligase: CBL

DEGRON score: 0.8325

ASA_SCORE: 54.7

COIL: 0.782

CONS_SCORE: 0.4678

DSS_SCORE: 0.0725

HELIX: 0.014

FCONS_SCORE: 0.7486

RIG_SCORE: 0.8718

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M172L	TCGA-3X-AAVA	CHOL	TCGA	DQYSMLP	CBL_PTK	0.5999
p.I184M	TCGA-92-7340	LUSC	TCGA	DQYSMLP	CBL_PTK	0.0556
p.R164Q	TCGA-AX-A0J0	UCEC	TCGA	DQYSMLP	CBL_PTK	0.2222
p.R164Q	TCGA-D1-A103	UCEC	TCGA	DQYSMLP	CBL_PTK	0.2222
p.I160S	TCGA-D1-A16X	UCEC	TCGA	DQYSMLP	CBL_PTK	0.1111
p.P177L	TCGA-EE-A2MR	SKCM	TCGA	DQYSMLP	CBL_PTK	0.25
p.V175M	DO51859	BLCA	ICGC	DQYSMLP	CBL_PTK	0.3056
p.R169M	DO223732	CESC	ICGC	DQYSMLP	CBL_PTK	0.8632
p.I161V	DO222798	COCA	ICGC	DQYSMLP	CBL_PTK	0.1389
p.S178C	DO49051	HNSC	ICGC	DQYSMLP	CBL_PTK	0.2222
p.R173Q	DO14192	HNSC	ICGC	DQYSMLP	CBL_PTK	0.7329
p.R173Q	DO229062	LICA	ICGC	DQYSMLP	CBL_PTK	0.7329
p.E172D	DO229006	LICA	ICGC	DQYSMLP	CBL_PTK	0.6758
p.L176M	DO43306	UCEC	ICGC	DQYSMLP	CBL_PTK	0.2778
p.K158N	DO41133	UCEC	ICGC	DQYSMLP	CBL_PTK	0.0556
p.V180M	SIDM01608	Endometrial Carcinoma	GDSC	DQYSMLP	CBL_PTK	0.1667
p.V180M	ACH-000990	Endometrial/Uterine Cancer	CCLE	DQYSMLP	CBL_PTK	0.1667
p.M165L	SIDM01611	Endometrial Carcinoma	GDSC	DQYSMLP	CBL_PTK	0.25
p.M165L	ACH-000996	Endometrial/Uterine Cancer	CCLE	DQYSMLP	CBL_PTK	0.25
p.Q169R	ACH-001441	Eye Cancer	CCLE	DQYSMLP	CBL_PTK	0.6218
p.D166N	no-11	central_nervous_system	COSMIC	DQYSMLP	CBL_PTK	0.2778
p.V164I	PANC-08-13	pancreas	COSMIC	DQYSMLP	CBL_PTK	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13995	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase	CBL_PTK	168:174	DQYSMLP	CBL	0.8325	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DQYSMLP

Degron related mutations and impact score

Drug responses associated with MTHFD2 mutations

All proteins holding degron of DQYSMLP