DegronMD - P14373(TRIM27)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E109K	DO225347	BRCA	ICGC	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.3056
p.E109Q	SIDM00845	Burkitt's Lymphoma	GDSC	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.3056
p.E109Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.3056
p.E109Q	SIDM01519	Head and Neck Carcinoma	GDSC	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.3056
p.E109Q	ACH-000786	Lymphoma	CCLE	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.3056
p.E109Q	ACH-000981	Leukemia	CCLE	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.3056
p.E109Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.3056
p.E109Q	DND-41	haematopoietic and lymphoid tissue	COSMIC	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.3056
p.Y106H	SIDM00789	Colorectal Carcinoma	GDSC	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation altering degron motif	0.6118
p.Y106H	ACH-000997	Colon/Colorectal Cancer	CCLE	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation altering degron motif	0.6118
p.Y106H	ACH-001061	Colon/Colorectal Cancer	CCLE	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation altering degron motif	0.6118
p.V95M	SIDM01617	Endometrial Carcinoma	GDSC	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.1111
p.V95M	ACH-000994	Endometrial/Uterine Cancer	CCLE	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation rewiring degron network	0.1111
p.K98E	ACH-001991	Primary	CCLE	LKLYCE	LIG_APCC_ABBA_1	103:108	Mutation blocking ubiquitination signal	0.6389

Kaplan plot for TRIM27 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM27

UniProt ID: P14373

Entrez ID: 5987

Protein name: Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (RING-type E3 ubiquitin transferase TRIM27) (Ret finger protein) (Tripartite motif-containing protein 27)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM27 in