DegronMD

Uniprot ID: P14373

Source protein: Zinc finger protein RFP

Source gene: TRIM27

Class: LIG_APCC_ABBA_1

Location: 103:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6564

ASA_SCORE: 51.7333

COIL: 0.251

CONS_SCORE: 0.7272

DSS_SCORE: 0.1638

HELIX: 0.0237

FCONS_SCORE: 1.2086

RIG_SCORE: 0.8175

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K98E	ACH-001991	Primary	CCLE	LKLYCE	LIG_APCC_ABBA_1	0.6389
p.Y106H	SIDM00789	Colorectal Carcinoma	GDSC	LKLYCE	LIG_APCC_ABBA_1	0.6118
p.Y106H	ACH-000997	Colon/Colorectal Cancer	CCLE	LKLYCE	LIG_APCC_ABBA_1	0.6118
p.Y106H	ACH-001061	Colon/Colorectal Cancer	CCLE	LKLYCE	LIG_APCC_ABBA_1	0.6118
p.E109K	DO225347	BRCA	ICGC	LKLYCE	LIG_APCC_ABBA_1	0.3056
p.E109Q	SIDM00845	Burkitt's Lymphoma	GDSC	LKLYCE	LIG_APCC_ABBA_1	0.3056
p.E109Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LKLYCE	LIG_APCC_ABBA_1	0.3056
p.E109Q	SIDM01519	Head and Neck Carcinoma	GDSC	LKLYCE	LIG_APCC_ABBA_1	0.3056
p.E109Q	ACH-000786	Lymphoma	CCLE	LKLYCE	LIG_APCC_ABBA_1	0.3056
p.E109Q	ACH-000981	Leukemia	CCLE	LKLYCE	LIG_APCC_ABBA_1	0.3056
p.E109Q	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LKLYCE	LIG_APCC_ABBA_1	0.3056
p.E109Q	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LKLYCE	LIG_APCC_ABBA_1	0.3056
p.V95M	SIDM01617	Endometrial Carcinoma	GDSC	LKLYCE	LIG_APCC_ABBA_1	0.1111
p.V95M	ACH-000994	Endometrial/Uterine Cancer	CCLE	LKLYCE	LIG_APCC_ABBA_1	0.1111

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14373	Zinc finger protein RFP	LIG_APCC_ABBA_1	103:108	LKLYCE	APC,CDC20,FZR1	0.6564	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons