DegronMD - P14415(ATP1B2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F113L	TCGA-AG-A002	READ	TCGA	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.3056
p.N118T	DO222421	BTCA	ICGC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.5944
p.D104Y	DO229022	LICA	ICGC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.D119G	SIDM00499	Prostate Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.7198
p.D119G	ACH-000956	Prostate Cancer	CCLE	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.7198
p.D119G	22RV1	prostate	COSMIC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.7198
p.Q124L	SIDM00969	Ovarian Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1944
p.Q124L	SIDM00317	Kidney Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1944
p.Q124L	SIDM00694	Other Solid Cancers	GDSC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1944
p.Q124L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1944
p.Q124L	SIDM00863	Burkitt's Lymphoma	GDSC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1944
p.Q124L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1944
p.Q124L	SIDM01387	Small Cell Lung Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1944
p.Y117H	SIDM00014	Colorectal Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.6118
p.Y117H	LIM1215	large intestine	COSMIC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.6118
p.A123S	SIDM00153	T-Lymphoblastic Leukemia	GDSC	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2222
p.A123S	ACH-000964	Leukemia	CCLE	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2222
p.D119N	ACH-001415	Bladder Cancer	CCLE	LEPYND	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.6932

Kaplan plot for ATP1B2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP1B2

UniProt ID: P14415

Entrez ID: 482

Protein name: Sodium/potassium-transporting ATPase subunit beta-2 (Adhesion molecule in glia) (AMOG) (Sodium/potassium-dependent ATPase subunit beta-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP1B2 in