DegronMD

Uniprot ID: P14415

Source protein: Sodium/potassium-transporting ATPase subunit beta-2

Source gene: ATP1B2

Class: LIG_APCC_ABBA_1

Location: 114:119

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8909

ASA_SCORE: 57.3167

COIL: 0.5097

CONS_SCORE: 0.5593

DSS_SCORE: 0.4049

HELIX: 0.4253

FCONS_SCORE: 1.3046

RIG_SCORE: 0.7878

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F113L	TCGA-AG-A002	READ	TCGA	LEPYND	LIG_APCC_ABBA_1	0.3056
p.N118T	DO222421	BTCA	ICGC	LEPYND	LIG_APCC_ABBA_1	0.5944
p.D104Y	DO229022	LICA	ICGC	LEPYND	LIG_APCC_ABBA_1	0.0556
p.D119G	SIDM00499	Prostate Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	0.7198
p.D119G	ACH-000956	Prostate Cancer	CCLE	LEPYND	LIG_APCC_ABBA_1	0.7198
p.D119G	22RV1	prostate	COSMIC	LEPYND	LIG_APCC_ABBA_1	0.7198
p.Q124L	SIDM00969	Ovarian Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	0.1944
p.Q124L	SIDM00317	Kidney Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	0.1944
p.Q124L	SIDM00694	Other Solid Cancers	GDSC	LEPYND	LIG_APCC_ABBA_1	0.1944
p.Q124L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LEPYND	LIG_APCC_ABBA_1	0.1944
p.Q124L	SIDM00863	Burkitt's Lymphoma	GDSC	LEPYND	LIG_APCC_ABBA_1	0.1944
p.Q124L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	0.1944
p.Q124L	SIDM01387	Small Cell Lung Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	0.1944
p.Y117H	SIDM00014	Colorectal Carcinoma	GDSC	LEPYND	LIG_APCC_ABBA_1	0.6118
p.Y117H	LIM1215	large_intestine	COSMIC	LEPYND	LIG_APCC_ABBA_1	0.6118
p.A123S	SIDM00153	T-Lymphoblastic Leukemia	GDSC	LEPYND	LIG_APCC_ABBA_1	0.2222
p.A123S	ACH-000964	Leukemia	CCLE	LEPYND	LIG_APCC_ABBA_1	0.2222
p.D119N	ACH-001415	Bladder Cancer	CCLE	LEPYND	LIG_APCC_ABBA_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14415	Sodium/potassium-transporting ATPase subunit beta-2	LIG_APCC_ABBA_1	114:119	LEPYND	APC,CDC20,FZR1	0.8909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons